Protein Info for LRK55_RS03040 in Rhodanobacter denitrificans MT42

Annotation: RIP metalloprotease RseP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 98 to 120 (23 residues), see Phobius details amino acids 373 to 395 (23 residues), see Phobius details amino acids 420 to 439 (20 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 7 to 446 (440 residues), 358.6 bits, see alignment E=2.2e-111 PF02163: Peptidase_M50" amino acids 11 to 433 (423 residues), 232.2 bits, see alignment E=1e-72 PF17820: PDZ_6" amino acids 130 to 181 (52 residues), 34.6 bits, see alignment 2.8e-12 amino acids 224 to 273 (50 residues), 46.4 bits, see alignment 5.6e-16 PF00595: PDZ" amino acids 135 to 169 (35 residues), 23.5 bits, see alignment 1.2e-08 amino acids 211 to 254 (44 residues), 28.1 bits, see alignment 4.3e-10

Best Hits

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 51% identity to xca:xccb100_2930)

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (448 amino acids)

>LRK55_RS03040 RIP metalloprotease RseP (Rhodanobacter denitrificans MT42)
MTSFFGSVFWLLVTLGVLVTFHEFGHYCVARRCGVKVLRFSVGFGNAIWKRIGRDGTEYQ
VAAIPLGGYVKMLDAREGEVDPALREQEFTGKPVWQRIAIVAAGPGFNLIFTIVAFWLMF
MLGRPDVAPVVTAAPQSLAASAGIQPGDRILRIDNRTVTTWTDTMDAVANALLGRAPLPL
TVRGQDGRTRELVLPLDELPPGQDVGQYLGKLGLKLAPPPAVAATVMPGQPAALAGMRGG
DRIVSVNGQPVEDFVAFGKLVQTAAAKSLTLAIGIEREGQPLRLNVTAKWESLEGQPPKW
VLGVGAPPVEAATVSYGPLKAMTASLDTTWRNTTQTFGMLGKMLTGEASTRNLSGVIGIA
EVANASAGMGLPWFLQFLALVSLSLAILNLLPIPVLDGGHLLYYLVELIKGSPVSEQAMV
VGQYIGLALLFTLMGLAFYNDIHRMLLS