Protein Info for LRK55_RS02785 in Rhodanobacter denitrificans MT42

Annotation: aminotransferase class III-fold pyridoxal phosphate-dependent enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 39 to 460 (422 residues), 235.4 bits, E=4.9e-74

Best Hits

KEGG orthology group: None (inferred from 84% identity to smt:Smal_1183)

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

• biotin biosynthesis I (14/15 steps found)
• biotin biosynthesis from 8-amino-7-oxononanoate I (4/4 steps found)

KEGG Metabolic Maps

• Biotin metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.62

Use Curated BLAST to search for 2.6.1.62

Protein Sequence (467 amino acids)

>LRK55_RS02785 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme (Rhodanobacter denitrificans MT42)
MNVFDKNASVVIDDAELLADEAKYSSFGDTVHYVDPPKIFRHGEGSYMFDTAGTPFLDLQ
MWYSAVNFGYGNKRLNDTLKRQIDLLPQVASQYLHQTRIELAKTVALDAKKKFGLDGRVH
FNVGGAQAIEDSLKLVRNYKNGKSLMFAFEGGYHGRTLGASSITSSYRYRRRFGHFGERA
MFLPFPYPFRRPKGMTAEEYSDACVNQFARLFETEYNGVWDPKTNQCEYAAFYVEPIQGT
GGYVVPPMNFFKDLKKVLDQYGILLVVDEIQMGFWRTGKLWSIEHFGVTPDVIVFGKALT
NGLNPLSGLWAREEMINPTIFPPGSTHSTFNSNPLGTALGLEVIKMGYELDYEKTVPVKG
AHFLEGLRGLQKKHKEIGDVDGLGLALRAEICTEDGFTPNKALLDRMVDIGLAGDLTHNG
KKIGLVLDVGGWYKNVITFAPSLDITHEEIDLAISLLDQLLTKAKKG