Protein Info for LRK55_RS01155 in Rhodanobacter denitrificans MT42

Annotation: ACR3 family arsenite efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 361 transmembrane" amino acids 27 to 45 (19 residues), see Phobius details amino acids 59 to 79 (21 residues), see Phobius details amino acids 98 to 120 (23 residues), see Phobius details amino acids 133 to 155 (23 residues), see Phobius details amino acids 168 to 191 (24 residues), see Phobius details amino acids 197 to 216 (20 residues), see Phobius details amino acids 236 to 254 (19 residues), see Phobius details amino acids 260 to 286 (27 residues), see Phobius details amino acids 298 to 321 (24 residues), see Phobius details amino acids 327 to 349 (23 residues), see Phobius details TIGR00832: arsenical-resistance protein" amino acids 21 to 348 (328 residues), 374.7 bits, see alignment E=2.3e-116 PF01758: SBF" amino acids 66 to 261 (196 residues), 110.8 bits, see alignment E=3.6e-36

Best Hits

Swiss-Prot: 44% identical to Y944_SYNY3: Uncharacterized transporter slr0944 (slr0944) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K03325, arsenite transporter, ACR3 family (inferred from 78% identity to sml:Smlt0176)

Predicted SEED Role

"Arsenical-resistance protein ACR3" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (361 amino acids)

>LRK55_RS01155 ACR3 family arsenite efflux transporter (Rhodanobacter denitrificans MT42)
MNQTPAELTACPAPAEGVRIGFFERWLTLWVLLCIVAGTLLGHLLPGSFEALGGMQVAQV
NLPVAVLIWLMIIPMLLKIDFGALGGVRRQWKGIGVTLFINWAVKPFSMALLGWIFIRHL
FAGQLPAAQLDSYIAGLILLAAAPCTAMVFVWSNLCRGEPAFTLSQVALNDAIMVVAFAP
IVALLLGISSITVPWNTLLLSVLLYIVVPVALSMLLRRQLLAHGGETRLQKLLQRLGPVS
LGALLATLVLLFGFQGRQILAQPAIIALLAVPILIQVYFNAGLAYWLNRRFGVPHCVAGP
SALIGASNFFELAVATAVGLFGVHSGAALATVVGVLIEVPVMLSVVRIVNRSKRWYEAAR
E