Protein Info for LRK54_RS17820 in Rhodanobacter denitrificans FW104-10B01

Annotation: mercury(II) reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 573 PF00403: HMA" amino acids 5 to 46 (42 residues), 31.3 bits, see alignment 5.5e-11 TIGR02053: mercury(II) reductase" amino acids 112 to 573 (462 residues), 594.2 bits, see alignment E=1e-182 PF07992: Pyr_redox_2" amino acids 112 to 430 (319 residues), 218 bits, see alignment E=5e-68 PF13738: Pyr_redox_3" amino acids 242 to 414 (173 residues), 32.2 bits, see alignment E=1.8e-11 PF00070: Pyr_redox" amino acids 284 to 349 (66 residues), 48.6 bits, see alignment E=2.4e-16 PF02852: Pyr_redox_dim" amino acids 449 to 557 (109 residues), 104.9 bits, see alignment E=6.9e-34

Best Hits

Swiss-Prot: 78% identical to MERA_ALCSP: Mercuric reductase (merA) from Alcaligenes sp.

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 78% identity to net:Neut_1309)

Predicted SEED Role

"Mercuric ion reductase (EC 1.16.1.1)" in subsystem Mercuric reductase or Mercury resistance operon (EC 1.16.1.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.16.1.1

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (573 amino acids)

>LRK54_RS17820 mercury(II) reductase (Rhodanobacter denitrificans FW104-10B01)
MNEQTLSVTGMTCADCARHVEKALKTLTDIVAADVAYPQGVAHIRSIQPMSLDQLNATLP
KNYRVAAAPPSHADTPAAKPSKLNQALDSLGGLFKPRGDGDTKPTDTEQRLRVAVIGTGG
AAMASALKAAELGAQVTVIERGTIGGTCVNIGCVPSKIMIRAAHVAHLRRTSPFDDGISS
TAPVVRRDRLLAQQQGRVDELRHAKYEGILDTSPNIQLLRGEARFKNANTLVVRSTVGDE
TEVSFDRCLIATGASAAVPPIPGLKDTPYWTSTEALVSGTIPPRLAVIGSSVVAVELAQA
FARLGSRVTILARSTLFFREDPAIGEAITTAFRAEGIDVLEHTQASLVAYTNGEFVLATG
HGEVRADQLLVATGRTANTRALALDAAGIAVNAQNAIVIDRGMRTSAPHIYAAGDCTDQP
QFVYVAAAAGTRAAINMTGGAATLDLTTMPAVVFTDPQVATVGLSEAEAHLKGTETDSRT
LSLDNVPRALVNFDTHGFIKLVAEAGNGRLIGVQAVTPEAGEIIQAAALAIRARMTVQEL
ADQLFPYLTMVEGLKLAAQTFTKDVKQLSCCAG