Protein Info for LRK54_RS17615 in Rhodanobacter denitrificans FW104-10B01

Annotation: copper resistance system multicopper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 589 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 10 to 588 (579 residues), 955.7 bits, see alignment E=9.2e-292 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 11 to 39 (29 residues), 22 bits, see alignment (E = 1.6e-08) PF07732: Cu-oxidase_3" amino acids 59 to 169 (111 residues), 132.2 bits, see alignment E=1.5e-42 amino acids 481 to 588 (108 residues), 25.4 bits, see alignment E=2e-09 PF00394: Cu-oxidase" amino acids 179 to 347 (169 residues), 79.8 bits, see alignment E=3.8e-26 PF07731: Cu-oxidase_2" amino acids 472 to 588 (117 residues), 104.5 bits, see alignment E=6e-34

Best Hits

Swiss-Prot: 62% identical to COPA_PSESM: Copper resistance protein A homolog (copA) from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

KEGG orthology group: None (inferred from 64% identity to rpi:Rpic_1779)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (589 amino acids)

>LRK54_RS17615 copper resistance system multicopper oxidase (Rhodanobacter denitrificans FW104-10B01)
MKILPPSAMDWSRRRFVQGVAFGGTVAALGLLRPSKAWALNTAGQPAILSGTDFALDIAE
TPVNYTGRPRLATTVNGSVPGPTLRWKEGTTVTLRVTNRLRVPTSIHWHGIILPFQEDGV
PGISFPGIAPGETFTYRFPVRQSGTYWYHSHSGFQEQTGLYGSLVIDPAGSERHPTARDY
VVMLNDWTDQNPEHILATLKRQSDYYNFAQPTAPEFFRDVREQGLRQALAERKMWNQMRM
NSTDLSDVSGYTYTYLMNGAAPAGNWTGLFKPGEKVRLRFINGSSMTIFDVRIPGLKLTV
ISADGQDVAPVPVDEFRISVAETYDVIVEPQEDRAFTIFAQSIDRTGYACGTLAPRPGMQ
AVVPAMDPRMPVSMVDMMGAMAQGGGHGGMSGMAGMAGMQDMPGMDMSGMATAAAPVVHH
ARTEYHNPGVDMHVDMPRTNLDDPGTGLRDNGRRVLTYADLHTIGGSIDPREPSREIELH
LTGNMERYMWSFDGVKFSDAKPVHFRSGERLRLVLVNDTMMNHPIHLHGMWSELENPDGQ
FQVRKHTINVQPAQRIAYGVSADNLGRWAYHCHMLYHMEAGMFREVVVS