Protein Info for LRK54_RS16735 in Rhodanobacter denitrificans FW104-10B01

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 824 PF02190: LON_substr_bdg" amino acids 14 to 204 (191 residues), 185.2 bits, see alignment E=3e-58 TIGR00763: endopeptidase La" amino acids 15 to 795 (781 residues), 1013.8 bits, see alignment E=0 PF07728: AAA_5" amino acids 356 to 480 (125 residues), 34.7 bits, see alignment E=3.4e-12 PF00004: AAA" amino acids 356 to 492 (137 residues), 75.7 bits, see alignment E=9.9e-25 PF05362: Lon_C" amino acids 593 to 796 (204 residues), 322.6 bits, see alignment E=2e-100

Best Hits

Swiss-Prot: 73% identical to LON_XANOR: Lon protease (lon) from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 75% identity to psu:Psesu_2042)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (824 amino acids)

>LRK54_RS16735 endopeptidase La (Rhodanobacter denitrificans FW104-10B01)
MAKNAPLPVALDALPVLPLRDVVVYPHMVIPLFVGRDKSMRALERAMEGERQILLVAQKS
PDIDDPEITDLHQVGTLAGVLQLLKLPDGTVKVLVEGQSRVSVEGFKEEDGMLTARSRVI
EPVYNAKERELDVVSRTLISLFEQLVKQSRKLPPEVLASLSGIDDPSRVADSIAAHLSVR
MADKQKVLETADVGQRLELLIGLVDGEMDLQQVEKRIRGRVKSQMEKSQREYYLNEQMKA
IQKELGDGEDGPNEIEELQKKIEGSGMPKAVLAKARQEFGKLKQMSPMSAEATVVRNYLD
WLVGVPWKKRSKVRKDLQLAQEVLDADHFGLEKVKDRILEYLAVQQRVSVMKGPILCLVG
PPGVGKTSLGQSIAKATNRKFVRMSLGGVRDEAEIRGHRRTYIGSMPGRIVQNINKVGTK
NPLFVLDEIDKMSMDFRGDPSSALLEVLDPEQNHAFNDHYLEVDLDLSEVMWIATANSLN
IPGPLLDRMEVIRIPGYTEDEKLGIAQKYLLSKQLKANGLKPEELSVTEDALRDIVRYYT
RESGVRNLEREISKICRKVVKELTLGQVKKARAKASPAKATKGRAKASPDRIKVDSSNLD
QYLGVRRFDFGRKELQNEVGLVTGLAWTQVGGELLSIEASVVAGKGRLVHTGQLGDVMKE
SIQAALSVVRARADQLGIDPEFHQKLDVHIHVPEGATPKDGPSAGIGMCTALVSALTRVP
VRSEVAMTGEITLRGRVLPIGGLKEKLLAAHRGGITTVIIPEDNKKDLVDMPANITSSLE
IHPVRWIDEVLDIALERPLQPNPAKEAAPAAVAGEPAEGHSLTH