Protein Info for LRK54_RS12165 in Rhodanobacter denitrificans FW104-10B01

Annotation: nucleoside permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 42 to 62 (21 residues), see Phobius details amino acids 71 to 89 (19 residues), see Phobius details amino acids 95 to 119 (25 residues), see Phobius details amino acids 135 to 154 (20 residues), see Phobius details amino acids 160 to 179 (20 residues), see Phobius details amino acids 212 to 231 (20 residues), see Phobius details amino acids 252 to 276 (25 residues), see Phobius details amino acids 283 to 301 (19 residues), see Phobius details amino acids 307 to 327 (21 residues), see Phobius details amino acids 348 to 369 (22 residues), see Phobius details amino acids 389 to 410 (22 residues), see Phobius details PF03825: Nuc_H_symport" amino acids 1 to 414 (414 residues), 438.6 bits, see alignment E=4.7e-135 TIGR00889: nucleoside transporter" amino acids 1 to 418 (418 residues), 504.9 bits, see alignment E=9.9e-156 PF12832: MFS_1_like" amino acids 6 to 374 (369 residues), 79.7 bits, see alignment E=4.6e-26 PF01306: LacY_symp" amino acids 8 to 372 (365 residues), 30.6 bits, see alignment E=3.2e-11 PF07690: MFS_1" amino acids 255 to 420 (166 residues), 46.9 bits, see alignment E=3.8e-16

Best Hits

Swiss-Prot: 56% identical to XAPB_ECOLI: Xanthosine permease (xapB) from Escherichia coli (strain K12)

KEGG orthology group: K11537, MFS transporter, NHS family, xanthosine permease (inferred from 65% identity to phe:Phep_2054)

MetaCyc: 56% identical to xanthosine:H+ symporter XapB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-31

Predicted SEED Role

"Nucleoside permease NupG"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>LRK54_RS12165 nucleoside permease (Rhodanobacter denitrificans FW104-10B01)
MSLKLRLTVLNFFQYYIWGAWLLTIGTWWFQTQHWSGTSFGAIFSTMGIASLFMPSLVGI
VADKWINAERLYGMLQIAGAMVLFAIPHVRDPEQMFWVMLLNMCFYMPTISLAITVAYNA
LKQDGLDVVNTYPPIRVWGTIGFIAATWTTSLLGFKASPAQFHVAAAASLLLGLYAFTLP
KCPPKLGAAQGRSLVDRLGLTSFVLFKNRNMAVFFLFAMLLGAALQLTNAYGDAFLSDFV
KVPEYANLLAVKYSTIIISISQFSETAFILTIPFFLKRFGIKAVMTMSMLAWVLRFGLFA
FGDPAGGLWMIVLSCIIYGMAFDFFNISGSLFVESQADPKIRASAQGLFMLMTNGVGAVL
GSLIAGFVIDHFFTNHACNDAVLICKDWHGIWLAFAGYALVMALLFVPLFKHRHDSAAAQ
RAVPTH