Protein Info for LRK54_RS11905 in Rhodanobacter denitrificans FW104-10B01

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 453 (23 residues), see Phobius details amino acids 463 to 485 (23 residues), see Phobius details amino acids 534 to 552 (19 residues), see Phobius details amino acids 861 to 881 (21 residues), see Phobius details amino acids 888 to 908 (21 residues), see Phobius details amino acids 914 to 938 (25 residues), see Phobius details amino acids 965 to 986 (22 residues), see Phobius details amino acids 992 to 1017 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 5 to 1018 (1014 residues), 1014.6 bits, see alignment E=0

Best Hits

Swiss-Prot: 47% identical to MDTC_ECO24: Multidrug resistance protein MdtC (mdtC) from Escherichia coli O139:H28 (strain E24377A / ETEC)

MetaCyc: 47% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1035 amino acids)

>LRK54_RS11905 efflux RND transporter permease subunit (Rhodanobacter denitrificans FW104-10B01)
MNIPELCIRRPVMTTLLMTALLVFGIVAYPQLPVNELPNVDFPTISISASLPGASPETMA
SAVATPLEGRLSAIAGISSMSSTSALGSTSITLSFELDRNIDAAAQDVQAAISSALRQLP
REMSTPPTFRKVNPADAAILYLAMSSSTLPLTQVDEYAETELAQQLSMIDGVAQVNVYGS
QKYAVRIGVDPDRLAAAGIGIDQVQSAIADANVNQSTGSLYGRRQQLPIRSDGQLLRAAA
YNDVVVAYRNGAPVHVGDIGRARDSVQNDQRSSSYNGKQAIVLAIQRQPGANTVATVDRI
KAVLPGFRAGLPPSITLDTLYDRSQSIRESVDDVQFTLLLAGALVVFVIYLFLGNLSATL
IPAVALPISVLGTFGVMYALGYSLDNLSLLALTLAVGFVVDDAIVMLENIVRHMEAGVPP
YQAALKGAGEVGFTIFSMTLSLIAVFIPVMFMGGIVGRLFHEFAVVISVAILISGIVAIT
LTPMLCSRFVKAHGHGDSDKSRKNWLIAGFDRGFAAVQRGYADSLHWCMERPRLVLAGFG
LSLLATALLFYATPKDFIPAGDNGQLRVNTEGPEDVSFEGMLARQQQLVDIVAKDPNIAG
YMSTVGAGGPRATINNGSILLLLKPAHQRKLGPDGIIQELRPKLASVAGIRSYIQNTPAI
QIGGRQSKAQYQYTLQSVSLDQLYEWSGKVTRAFAALPGFEDVTNDLDLNSPSIMVKVDR
AKLAPLGLTMAQVQTALGIGFGQNQVSTIYGSATQYWVILQVERKLQDDPAVLSQLYVTS
NRGSLVPLSAVASFSREPQALTVNHQGQLPAVTVSFNLAPGVPLSDAVASINGAMGKLGL
PATISGSVQGTAQAFQQSMQGMGMLLLLAVFVIYLVLGILYESFIHPLTILSGLPAAAVG
ALLTLAIFHASLDLFAFVGIVMLIGIVKKNAIMLIDFALERQREEGMAPAQAIAEACRVR
FRPIMMTSMAAMAGTLPIALGIGAGAEVRRSLGLAVVGGLVFSQILTLYLTPVIYIYMDQ
LQQRFARSGRALPAR