Protein Info for LRK54_RS11900 in Rhodanobacter denitrificans FW104-10B01

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 369 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 41 to 364 (324 residues), 268.9 bits, see alignment E=2.6e-84 PF16576: HlyD_D23" amino acids 54 to 286 (233 residues), 50.6 bits, see alignment E=2.4e-17 PF13533: Biotin_lipoyl_2" amino acids 66 to 113 (48 residues), 33.4 bits, see alignment 4.6e-12 PF13437: HlyD_3" amino acids 177 to 283 (107 residues), 33.3 bits, see alignment E=1e-11

Best Hits

KEGG orthology group: K07799, putative multidrug efflux transporter MdtA (inferred from 39% identity to gur:Gura_2372)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (369 amino acids)

>LRK54_RS11900 efflux RND transporter periplasmic adaptor subunit (Rhodanobacter denitrificans FW104-10B01)
MSWKKIALVVAALLAVALAMHFSRGRGDSSKAARAPAAVPVEVASATRGDVELSLKLVGR
VEAWSTVSLRARVSGQLQSLSFTPGALVRKGSMLAQIDPRLLRAQLDQARGSVARDLALL
QKAQADQRRYADMLGKGFVSKADYDLYQANLAVARATLQSDRAAQELAQTQLDYARIVAP
FDGITGAPLVWPGAQISADSTDIVVLNQVEPVRVAFNIPEDSLPAVRAALASGAVAVQVT
VSGDKGTPLAGTLEFIDNAVDATTGTIVLKARFDNAGHRLTPGQFVQVSLPTTRLANVVS
VPVHALQSSSGGNFVFVLGADGKVRQRFVTPGPTSGGRTVIDKGLKAGEQVVTEGQMLLV
DGSAAVVKG