Protein Info for LRK54_RS10020 in Rhodanobacter denitrificans FW104-10B01

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 883 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 299 to 319 (21 residues), see Phobius details PF03924: CHASE" amino acids 90 to 250 (161 residues), 83.9 bits, see alignment E=2e-27 TIGR00229: PAS domain S-box protein" amino acids 337 to 452 (116 residues), 25.3 bits, see alignment E=1.4e-09 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 454 to 618 (165 residues), 126.1 bits, see alignment E=1.2e-40 PF00990: GGDEF" amino acids 458 to 616 (159 residues), 130.3 bits, see alignment E=8.8e-42 PF00563: EAL" amino acids 638 to 875 (238 residues), 204.4 bits, see alignment E=2.7e-64

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (883 amino acids)

>LRK54_RS10020 EAL domain-containing protein (Rhodanobacter denitrificans FW104-10B01)
MTAHGRGDPDGALPRPSPWRLAAWLWSLLALLSGLALTMVMHHQQQQRLQVERTLIRDEL
ANKTYASLQSRLYAAESLLRAAQSLFLSSEEVDAGEYAGFYANMRPREQFPNLLALAYAQ
RERRPDGEHYVTRWVQPASGNERVVGLDVGTQPHNLAGLLASRDSDRATLSAPFHPVQLA
ASGMAGIGATLRLPIYSSGPPPQTAEERRSRMRGSIAASFRLHDLIASALPERLAHNLRL
QISDVTGPQALPLYDSGTGPWWSRDGYRYERKLAYGGRVWSVELRPLPHRVGVIGGGRAI
LLAGVLASVLLALLVYSVASARQRALAQGWRMSRRYRESEERFRALNDLLPALVLLAEAG
DGAITYANQASRDRLGQHVTERKLPELFEDRDLRTQLQQDDTRGCGRVDAILRSDAGDGF
WASVAISRVMLSGRSKLLMVASDISEQRQLTELLSHQASHDALTELYNRREFERRLHRAL
DATVAGTPLAVLLYIDLDQFKLINDTSGHLAGDQLLAQLAIVMRKQLGGTDMLARLGGDE
FGVLVTGVADRAEAERIAERVRRCIDGYVFIWEQRSYMISASIGGVMIDRPGILVKDLLA
QADTACYMAKELGRNRVHFYSERDDQTSRRHSEMEWANRLRWAVDEHRLVLTYQEIWPLP
LAAGGDTDIEMLLRFREESGQLVVPGVFMPAAERYGLMPVVDRWVIETTLANFDRLHPSG
GMLRMVAINLSGASVEDERLAGRIIDLLRRYRVEPSRVCFEITETVAVRNLSQVARFMEQ
LRAVGCRIALDDFGAGMSSFTYLKNLPLDILKIDGSFVRDMLTDPVSHLMVRAVTDIGHR
LGLEVVAEWVADAETVQALAALGVNWVQGFSLHRPELALFQRD