Protein Info for LRK54_RS07580 in Rhodanobacter denitrificans FW104-10B01

Annotation: Na+/H+ antiporter subunit E

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 162 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details transmembrane" amino acids 64 to 84 (21 residues), see Phobius details amino acids 105 to 124 (20 residues), see Phobius details PF01899: MNHE" amino acids 13 to 160 (148 residues), 142.6 bits, see alignment E=4.1e-46

Best Hits

Swiss-Prot: 47% identical to PHAE_RHIME: Probable K(+)/H(+) antiporter subunit E (phaE) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K05562, multicomponent K+:H+ antiporter subunit E (inferred from 57% identity to pzu:PHZ_c2146)

Predicted SEED Role

"Na(+) H(+) antiporter subunit E" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (162 amino acids)

>LRK54_RS07580 Na+/H+ antiporter subunit E (Rhodanobacter denitrificans FW104-10B01)
MIRRWLPYPILSALLLAVWLLLQQSVAPGTILLGALLGVALAKVFGLLRPPKARLRHYPL
LGRLFLRVVLDIFRSNLAVARLILRRDSRTRSGFVAIPLALTDHYGLAVLACIITSTPGT
IWVSYDSSANILLIHVLDLVDEAIWIDSIKQRYERPLLEIFQ