Protein Info for LRK54_RS07120 in Rhodanobacter denitrificans FW104-10B01
Annotation: cytochrome c oxidase subunit I
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 57% identical to COX1_RICFE: Probable cytochrome c oxidase subunit 1 (ctaD) from Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 73% identity to aeh:Mlg_0294)MetaCyc: 72% identical to cytochrome c oxidase subunit 1 (Pseudomonas putida KT2440)
Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (1/2 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1
Use Curated BLAST to search for 1.9.3.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (538 amino acids)
>LRK54_RS07120 cytochrome c oxidase subunit I (Rhodanobacter denitrificans FW104-10B01) MSYAATHDQHDDHHGAPKGFFQRWCMSTNHKDIGTLYLIFSLTMLFIGGSFAMLIRAELF KPGMQLMQPYFFNEMTAMHALVMIFGAIMPAFVGLGNWMIPLMVGAPDMALPRMNNLSFW ILPFAFVLLLSTLFLPGGGPAGGWTMYPPLSLQSGSLAYAVFAIHLMGISSIMGAINIIA TILNMRAPGMDLMKMPVFVWSWLITAFLLIAVMPALAGAVTMLLTDKYFGTNFFNPGGGG DPVLYQHIFWFFGHPEVYIMILPAFGIISEIVPTFARKPIFGYKAMVFAIACIAFLSFIV WAHHMFAVGLPLGAEVFFMYATMLISVPTGVKVFNWVATMWGGSMTFETPMLFAIAFIIL FTIGGFSGLMMALVPADFQYHDTYFIVAHFHYVLVTGALFAIIGAAYYWMPKWTGNMYNE FWGKVHFWNSVIWVNVLFFPQHFLGLAGMPRRIPDYNVAFANFNMISSIGGFLFGATQLI FVGVLIHCVFFSKKKATDRVWEGAKGLEWTIPSPAPHHTFEVPPVINDDELAHGHVND