Protein Info for LRK54_RS06865 in Rhodanobacter denitrificans FW104-10B01

Annotation: uroporphyrinogen-III C-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 transmembrane" amino acids 49 to 70 (22 residues), see Phobius details PF04375: HemX" amino acids 156 to 342 (187 residues), 59.3 bits, see alignment E=2.3e-20

Best Hits

Predicted SEED Role

"Distant homolog of E. coli HemX protein in Xanthomonadaceae" in subsystem Heme and Siroheme Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (382 amino acids)

>LRK54_RS06865 uroporphyrinogen-III C-methyltransferase (Rhodanobacter denitrificans FW104-10B01)
MSNVDQPNASAAPEGARPDPAATGALPVDPPMRASRAAPAQPAPRRGGGSVALAVLLALL
AVAAAGYVGWRQWQQAQGGAAEQRNVASLQQRVATLETTLTALDDQRGSLNQRLDDAAQV
NRSLREELLGQAERTRHLEDAVAKLAEKSLSGRDGMLLGEAESLLRMAGERYTLFHDAQG
AAAAYALADQTLAAVNDGAFSSLRQSVNAEREALVKSQPASQAGALQQLVALRGALATLP
LKPLDSGATEATDAWSRIRRALTGVVSVQRDDGAPLAVADARFARELAALDLAQAQAALL
AHDAKGYAAALQRVDAALASQFDGHAPAVQQAREALRQLASQLPANAPVQLGAALGELRN
LRAVHALSPAPGGSAPSGGARP