Protein Info for LRK54_RS06645 in Rhodanobacter denitrificans FW104-10B01

Annotation: prolyl oligopeptidase family serine peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 694 PF02897: Peptidase_S9_N" amino acids 20 to 409 (390 residues), 88.3 bits, see alignment E=5e-29 PF00326: Peptidase_S9" amino acids 491 to 693 (203 residues), 151.5 bits, see alignment E=2.4e-48

Best Hits

KEGG orthology group: K01322, prolyl oligopeptidase [EC: 3.4.21.26] (inferred from 61% identity to vpe:Varpa_5466)

Predicted SEED Role

"Prolyl endopeptidase (EC 3.4.21.26)" (EC 3.4.21.26)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.26

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (694 amino acids)

>LRK54_RS06645 prolyl oligopeptidase family serine peptidase (Rhodanobacter denitrificans FW104-10B01)
MNDSHARDTTPAPAATPTGDDPFLWLEDIHGARALDWVKQQNATTAKQFVDNAEFARTRD
RILEVLDSEARIPYVNRMGDHLYNFWRDKAHPRGIWRRTTLAEYRKAEPAWELLLDVDAL
NQAEGKRWVFKGVQCLKPAYERCLISLSPDGGDAVAVREFSIPHKAFVKDGFVLPVAKSE
VDWIDEDTLYVGTDFGPGSMTESSYPRIVKEWKRGTPLAAAATVYEGKPSDLAVSAHHDR
TPGYERDFVSIARDFYHSDLYQRLGDKLVRVEVPADAEAEAHRDWLLVRTRSPWTVDGST
YPAGALLATPFDPFMAGKRHFTMLFEPDAHTSLDSYAWTKNHLILNLMDDVKSRLEVLTP
PQVATPGGDWKRAAMAGAPAMSTINVIDTDPDHSDEYWLDVTGFLAPSSLRHGVLGGAAA
EKVKQAPAFFDAAKFAVSQHFVQSKDGTRVPYFEIAPKDLKLDGANRTLLYGYGGFEVSL
QPQYSGSVGRAWLERGGVYVIANIRGGGEYGPQWHQAALKANRPRAYEDFAAVAEDLVKR
GVTSAQHLGAEGGSNGGLLMGNMLTMYPQLFGAIACEVPLLDMKRYIHLSAGASWMAEYG
NPDTSDWNFIKTFSPYQNVRKDGRYPPVLFYTATSDDRVGPVQARKMAARIQAQGHPNVW
FYENLEGGHGAGADNRQSAHMHAMAYDFLWDQLQ