Protein Info for LRK54_RS04230 in Rhodanobacter denitrificans FW104-10B01

Annotation: HAMP domain-containing histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 422 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 133 to 156 (24 residues), see Phobius details PF00512: HisKA" amino acids 213 to 273 (61 residues), 42.3 bits, see alignment E=6.2e-15 PF02518: HATPase_c" amino acids 326 to 418 (93 residues), 43.8 bits, see alignment E=3.1e-15

Best Hits

KEGG orthology group: None (inferred from 47% identity to psu:Psesu_2154)

Predicted SEED Role

"two-component system sensor protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (422 amino acids)

>LRK54_RS04230 HAMP domain-containing histidine kinase (Rhodanobacter denitrificans FW104-10B01)
MGRETSLKQRMVSGIVIYSLFLTLALLAYGYLVNERAETLVWESLLNTELDHFLERHRLD
PDYRWNDSETLTLYGTLVGHEPPIEFRSLDVGVHDEVVVGSKEFVVLVRAIGGDHAVLAL
NISGMGSSRSGLNALVIGSAAAMVALLTFATAMGVGRLTKPLGDLARRIVDLRPAISGQR
LVIAEGESAEIGVVMRAFNDYLGRMDQAVERERTFLNMASHELRTPVAVIRSSTELALSQ
HDISAMTQRYLQRIRQTAEGMDELLALVLVLAKDPVRLLKHSEMTDLGALIPEIVNDHRP
LMSGKALAFEIGTLPSVWIEAPPQIVRAAIGNLIRNAIENSDAGTIRVSLELPAQVVISD
PGHGMTAVEISRVYSRHAREIGLGRDGIGLELIGRLCEHLGWTLELTSGGGTGTTASLAF
AH