Protein Info for LRK54_RS04035 in Rhodanobacter denitrificans FW104-10B01

Annotation: ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 46 to 67 (22 residues), see Phobius details amino acids 77 to 96 (20 residues), see Phobius details amino acids 100 to 118 (19 residues), see Phobius details amino acids 123 to 144 (22 residues), see Phobius details amino acids 156 to 178 (23 residues), see Phobius details PF00512: HisKA" amino acids 210 to 271 (62 residues), 39.8 bits, see alignment E=4e-14 PF02518: HATPase_c" amino acids 317 to 419 (103 residues), 55.6 bits, see alignment E=6.8e-19

Best Hits

KEGG orthology group: K15011, two-component system, sensor histidine kinase RegB [EC: 2.7.13.3] (inferred from 42% identity to hha:Hhal_1420)

Predicted SEED Role

"Sensor histidine kinase PrrB (RegB) (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (424 amino acids)

>LRK54_RS04035 ATP-binding protein (Rhodanobacter denitrificans FW104-10B01)
MPHRSTQRIGLFALTRTLAWLRICAIAGQSAAVLVCAWWMQLAIPLLPLLLGIGLLAVFS
VFAAWRLTQPWPLREWEAVGHIAFDTLVLGYLLYFTGGASNPFITLLLVPIALSAAALPG
RAVLTVAALAGVAYVSLLYSYVPLPLPMAADSPSRFTLHVVGMGVNFVIMALLLSFFISR
LAHVLRLQQLEVQRVRERALRDEGILAIATQAAGAAHELNTPLSTMRTLLPELRREHADD
ETLAEDLALLESQVDRCRTILREMVAFGKAQLSQEPERLTVAVFIHGCLERFQLLRPEAE
VTLPLDEDVARIVLRTPPGLRHALLNLLNNAADASAINHSNAVALHVSRDGEWLQLSVRD
HGPGFDTEGELTLLGYSRKQTGLGIGLALAEATAERLNGELIASNTARGAEVCLRLPLAV
IAER