Protein Info for LRK54_RS01990 in Rhodanobacter denitrificans FW104-10B01

Annotation: copper resistance system multicopper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 583 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 10 to 582 (573 residues), 959.5 bits, see alignment E=6.6e-293 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 12 to 40 (29 residues), 28 bits, see alignment (E = 2e-10) PF07732: Cu-oxidase_3" amino acids 61 to 170 (110 residues), 126.7 bits, see alignment E=8e-41 amino acids 475 to 582 (108 residues), 24.2 bits, see alignment E=4.5e-09 PF00394: Cu-oxidase" amino acids 180 to 342 (163 residues), 85.7 bits, see alignment E=5.8e-28 PF07731: Cu-oxidase_2" amino acids 467 to 582 (116 residues), 102.3 bits, see alignment E=2.8e-33

Best Hits

Swiss-Prot: 63% identical to COPA_PSESM: Copper resistance protein A homolog (copA) from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

KEGG orthology group: None (inferred from 61% identity to rme:Rmet_6112)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (583 amino acids)

>LRK54_RS01990 copper resistance system multicopper oxidase (Rhodanobacter denitrificans FW104-10B01)
MNPFSPPPATDLSRRRFVQGLALGGAAAGLGLLRPPNVWALTSPGQPSVLGGTEFVLDIV
EATVNFTGAARPAATVNGGVPGPLLRMREGTTVNLRVSNRLRVPTSIHWHGIILPFRMDG
VPGLSFDGIAPGESFVYRFQLRQSGTYWYHSHSGFQEQNALYGPLVIEPAGRERYPADRD
YVVMLNDWTDEDPARIYARLKKQSDYYNFAQPTVPDFFRDVREKGLRQALAMRRMWNTMR
MNPTDLGDVSGYTYTYLMNGTTPAGNWTGIFRPGEKIRLRFINGSSSSIFDVRIPGLKMT
VIAADGQDVQPVAVDEFRISAAETYDVIVEPQEERAYTLFAQSIDRSGYARGTLAPRAGM
EAEVPALDRRLWLGMQDMMGAMSHADHGGGHAAMPGMEHGGVAGMATSPAPVVRHARTEY
GPGVDMRVDTPRSNLDDPGIGLRDNGRRALTYADLHTVGGPLDAREPGREIELHLTGNME
RFMWSFDGIKFPDAKPIHFNTGERLRIVLVNDTMMNHPIHLHGMWSELENPHGQFQVRKH
TINVQPVQRITYAVTADAPGRWAYHCHLLYHMEAGMFREVVVA