Protein Info for IKLFDK_17450 in Pseudomonas aeruginosa PA14

Annotation: ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 transmembrane" amino acids 20 to 37 (18 residues), see Phobius details amino acids 175 to 197 (23 residues), see Phobius details amino acids 221 to 242 (22 residues), see Phobius details amino acids 254 to 274 (21 residues), see Phobius details amino acids 284 to 304 (21 residues), see Phobius details amino acids 345 to 365 (21 residues), see Phobius details PF12698: ABC2_membrane_3" amino acids 21 to 361 (341 residues), 119.6 bits, see alignment E=1.7e-38 PF01061: ABC2_membrane" amino acids 217 to 329 (113 residues), 57.4 bits, see alignment E=1.5e-19

Best Hits

KEGG orthology group: K09686, antibiotic transport system permease protein (inferred from 100% identity to pae:PA3400)

Predicted SEED Role

"ABC-type multidrug transport system, permease component"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (377 amino acids)

>IKLFDK_17450 ABC transporter permease (Pseudomonas aeruginosa PA14)
MKNYLQILRETLKAMLSKPMWLMVVASVCITSLPYMNHTALDLPVAVVDEDHSDVSRELV
RLLDSAPKVAVVGYDSLPQAKRDLAWRELYAIIVIPLNFEKRLLRGEALVIPYFGDATNR
MANGQIQQDISAVYSALTNRYNAALLEREGFTATQAQVVLSPLVGQLTDLFNPGISFAAI
VLPGLLSLILQHSLLLGCTRGNIMLRGGTPRYMRQPLSTRFGRYSAQLLIWTVLAMLFYV
IWPHLLGYRQSASFFMLLGIVLPFLIAVIALSEFIAELLPTEESVYLTMTFITLPLFYMA
GYSWPEQAMPDWVRWLADAIPSTWAIRAIAEMNQMDLPLREVSDHALVLLGMAATYALLG
TLLYQYRNWRWDNIKGW