Protein Info for IKLFDK_12040 in Pseudomonas aeruginosa PA14

Annotation: Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 511 PF14532: Sigma54_activ_2" amino acids 203 to 374 (172 residues), 73.1 bits, see alignment E=8.2e-24 PF00158: Sigma54_activat" amino acids 203 to 369 (167 residues), 222.4 bits, see alignment E=9.1e-70 PF18024: HTH_50" amino acids 460 to 507 (48 residues), 51 bits, see alignment 2.8e-17 TIGR04381: TyrR family helix-turn-helix domain" amino acids 461 to 508 (48 residues), 83.7 bits, see alignment 3.4e-28

Best Hits

KEGG orthology group: None (inferred from 100% identity to pap:PSPA7_2801)

Predicted SEED Role

"transcriptional regulator, MerR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (511 amino acids)

>IKLFDK_12040 Fis family transcriptional regulator (Pseudomonas aeruginosa PA14)
MRIHVSFIDRVGITQEVLALLGGRNLNLDAVEMVPPNVYIDAPTLSPEVLEELRAALLGI
RGVQAMTVVDILPGQRRRLQLDALLAAMADPVLAVDGKGLVLLANPAFSERCGRDPAGER
LASLFDDETLEDALVEQGFRLPLREVTFMGQALLLDATPITEGPGEGERHLAGGLLTLYE
PNRIGERLAALHHDHAEGFEMLLGDSQPIRTLKTRAQRVAALDAPLLIHGETGTGKELVA
RGCHALSARHNSPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLLELAHQGTVF
LDEIGEMSPYLQAKLLRFLSDGSFRRVGGDREVRVDVRILSATHRNLEKMVAEGSFREDL
FYRLNVLSLEVPPLRERGHDILLLARHFMQQACAQIQRPVCRLAPGTYPALLSNRWPGNV
RQLQNVIFRAAAICESSLVDIGDLEIAGTAVARQNDGEVGSLEEAVEGFEKALLEKLYVS
YPSTRQLAARLQTSHTAIAHRLRKYGIGPRA