Protein Info for IKLFDK_03040 in Pseudomonas aeruginosa PA14

Annotation: Amino acid adenylation domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1152 transmembrane" amino acids 747 to 765 (19 residues), see Phobius details amino acids 785 to 803 (19 residues), see Phobius details amino acids 1113 to 1131 (19 residues), see Phobius details PF00668: Condensation" amino acids 127 to 526 (400 residues), 117.9 bits, see alignment E=1e-37 PF00501: AMP-binding" amino acids 563 to 908 (346 residues), 265 bits, see alignment E=2e-82 TIGR01733: amino acid adenylation domain" amino acids 581 to 979 (399 residues), 403.9 bits, see alignment E=3.5e-125 PF13193: AMP-binding_C" amino acids 963 to 1036 (74 residues), 35.8 bits, see alignment 2.6e-12 PF00550: PP-binding" amino acids 1066 to 1131 (66 residues), 35.7 bits, see alignment 1.7e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to pau:PA14_54930)

Predicted SEED Role

"Siderophore biosynthesis non-ribosomal peptide synthetase modules"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1152 amino acids)

>IKLFDK_03040 Amino acid adenylation domain-containing protein (Pseudomonas aeruginosa PA14)
MNTFHASDFIAKIQALLPEPFAGREEDNLIELGLDSLHIMRLVNDWRREGIALTFAQLIE
RPYLKHWLQLLETVRPNAPTETAAWQPDSLEASTPIDGAEAFGLTDVQYAYWVGRQDGQP
LGGVGCHAYLELEGRGIDPSRLEGGWQQLFRQHAMLRTRFGTDGTQCVCEDLAAPPLRTH
DFRHLAANEAEARLLAVRDRLSHRRLDVAIGEVAGLELSLLPGGGTCIHFDIDLLVADVQ
SLHILLRDLAAAYQGQALRADPDWRFSQYLNSEARRGAEQVDIAQKYWQDSLAKLPPGPQ
LPLVKTPENVVRPRFVRRRHQLPSETWQTLRRLAARNGVTPAMMLLSAYAEVLGRWSQEP
EFSLNLPLFDRRTDHPGVEHVVADFTNLLLLRCDCRHAASFSDRTHELQRQFHRDVAHSS
YSAVNVQRDMVKHGFAEGVMAPVVFACNLGTPLLTPECKTTLGRLRYMVSQTPQVWLDHQ
VYEDEEGLLLAWDAVEELFPEGVVDDMFSAYCNLLEWLAQDATHWQQLMPWVRRSHEQDI
RTAAVVDNGIVTDASLHQRMFNVAATMPDRVAVVLDGGVLSYGELARRALQVAALLHRHG
IEPGEPVAISLPRGLDQVTAVFGVLAAGACYVPVGMSQPAARQARIHETAGIRWVLTDSS
GVVMATREGTTRLDVASAWHIDPPSEYQPVRADSSAYIIFTSGSTGEPKGVEVTHAAAAN
TIDVLNARYGVGPDSRVLAVSSLDFDLSVYDLFGVLGVGGAVVLLDEDHRRDAAAWLELI
HQHRVTLWNSVPVLLDMLLVMAAEDPRPLPFEQVFLSGDWIGLDLPGRLFAKTSGSTKLV
AMGGATEAAIWSNAFDVTLPLPAHWRSIPYGRPLANQRYRVVDAQGRDCPDWVTGELWIG
GAGVALGYRGDPAQTAERFVDYNGERWYRTGDLGRYWPDGNLEFLGRRDHQVKVRGHRIE
LGEIEAALSALPGVARAVAVTIGKPVALAAAFVPTDPTTQPRTDELLAALRQLLPDYMVP
THLQAIDTLPLSGNGKVDRQALVALLATQASTRAAYDPPQPGLECEVADIWREVLQCTPL
SRTDDFFLIGGDSLRATQIVQLLHSRRISPAPVPLFVLFSSPTIAALAHHIRGQWQALSM
TGAEDSIEEGIL