Protein Info for IAI47_20005 in Pantoea sp. MT58

Annotation: PTS sugar transporter subunit IIA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00359: PTS_EIIA_2
  • amino acids 8 to 147 (140 residues), 115 bits, E=1.4e-37

Best Hits

Swiss-Prot: 40% identical to PTMA_ECOLI: Mannitol-specific cryptic phosphotransferase enzyme IIA component (cmtB) from Escherichia coli (strain K12)

KEGG orthology group: K02821, PTS system, ascorbate-specific IIA component [EC: 2.7.1.69] (inferred from 86% identity to pva:Pvag_pPag30336)

MetaCyc: 40% identical to mannitol-specific PTS enzyme IIA component CmtB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-156 [EC: 2.7.1.197]

Predicted SEED Role

"PTS system, IIA component"

KEGG Metabolic Maps

• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Starch and sucrose metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.197 or 2.7.1.69

Protein Sequence (149 amino acids)

>IAI47_20005 PTS sugar transporter subunit IIA (Pantoea sp. MT58)
MSHLAKWLNNEKIQYVESVADWQEALVIAGRPLLSEGTISQDYIDAIIQQKEEIGPFFVI
APQIAMPHARPEQGAHKLGLSIVLLGTAVKFDSEENDPVKAIFMFAAPDSNSHIEMISEL
AEVLSDEAIMTQLFRATSKEALITILSGV