Protein Info for IAI47_18570 in Pantoea sp. MT58

Annotation: lipid A ABC transporter ATP-binding protein/permease MsbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 585 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 60 to 92 (33 residues), see Phobius details amino acids 95 to 105 (11 residues), see Phobius details amino acids 151 to 162 (12 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 245 to 268 (24 residues), see Phobius details amino acids 274 to 293 (20 residues), see Phobius details TIGR02203: lipid A export permease/ATP-binding protein MsbA" amino acids 11 to 580 (570 residues), 846.4 bits, see alignment E=5.1e-259 PF00664: ABC_membrane" amino acids 27 to 296 (270 residues), 207 bits, see alignment E=6.9e-65 PF00005: ABC_tran" amino acids 358 to 508 (151 residues), 124.6 bits, see alignment E=6.8e-40

Best Hits

Swiss-Prot: 79% identical to MSBA_ECO57: Lipid A export ATP-binding/permease protein MsbA (msbA) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 94% identity to pva:Pvag_3371)

MetaCyc: 79% identical to ATP-binding lipopolysaccharide transport protein (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-236 [EC: 7.5.2.6]; 7.5.2.6 [EC: 7.5.2.6]

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (585 amino acids)

>IAI47_18570 lipid A ABC transporter ATP-binding protein/permease MsbA (Pantoea sp. MT58)
MFDNDLSTRQTFSRLWPTISPFRLGLVVAGVALIVNAAIDPLMLTLLKTLLDDVIGRNNH
GILIWMPLVIIGLILVRGVSGYISSYCISWVSGKVVMALRCRLFSHMMGMPVAFFDQQST
GTLLSRISYDCEQVASSSSGSLVTVVREGASILGLFVMMFYYSWQLSLILLVLAPIVSLA
IRIVSRRFRGISKNMQNTMGQVTSHAEQMLKGHKEVLMFGGQQVETTRFEQVSNNMRRQG
MKMVSATSLSDPIIQLLASSALAFVLYAASFPSVMATLTAGSISAVFSAMLMLMRPLKSL
TNVNAQFQRGMAACQTLFAILDTEQEKDEGTYVVERATGNIEFRDVTFTYPGSETPALEH
INLTIPAGKTVALVGRSGSGKSTLASLLTRFYDIDSGEILLDGHALRDYTLASLREQVAL
VSQHVHLFNDTVANNIAYARTDVFSREAIEKAAQMAHAMEFINKMDNGLDTVIGENGVLL
SGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQSALETLQQNRTTLIIAHRLST
IEKADEILLVEEGRIVERGSHQQLLQKNGAYTRLYKMQFSQPLCA