Protein Info for IAI47_18565 in Pantoea sp. MT58

Annotation: sugar kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 4 to 306 (303 residues), 229.1 bits, E=4.1e-72

Best Hits

Swiss-Prot: 72% identical to KDGK_ECOLI: 2-dehydro-3-deoxygluconokinase (kdgK) from Escherichia coli (strain K12)

KEGG orthology group: K00874, 2-dehydro-3-deoxygluconokinase [EC: 2.7.1.45] (inferred from 94% identity to pva:Pvag_3373)

MetaCyc: 72% identical to 2-dehydro-3-deoxygluconokinase (Escherichia coli K-12 substr. MG1655)
2-dehydro-3-deoxygluconokinase. [EC: 2.7.1.178, 2.7.1.45]

Predicted SEED Role

"2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 2.7.1.45)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (5/5 steps found)
• D-galacturonate degradation I (5/5 steps found)
• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• D-galactonate degradation (3/3 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• L-glucose degradation (3/7 steps found)
• alginate degradation (2/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.45

Use Curated BLAST to search for 2.7.1.178 or 2.7.1.45

Protein Sequence (310 amino acids)

>IAI47_18565 sugar kinase (Pantoea sp. MT58)
MTHKKIAIIGECMIELSEKGENIKRGFGGDTLNTAVYLARQVDEQQLRVDYVTALGTDSF
SDQMIAAWQQEKVNTDLIQRLDNKMPGLYVIETDADGERTFWYWRSDAAARYWLDSPQSE
EIAGQLSHYDYLYLSGISLAILPPSSREKLMTLLARCRANGGKVIFDNNYRPRLWADRAS
AQAAYRAMLNCTDIAFLTLDDEHLLWGEAPLEEVIARTRQAGASEIVIKRGADSCLVVTG
DAPLIDVPAVRLAKEKVIDTTAAGDSFSAGYLARRLTGASAEEAAQRGHLTASIVIQHRG
AIIPAEAMPE