Protein Info for IAI47_18420 in Pantoea sp. MT58

Annotation: class I adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 852 PF12633: Adenyl_cycl_N" amino acids 5 to 200 (196 residues), 255.4 bits, see alignment E=4.6e-80 PF01295: Adenylate_cycl" amino acids 228 to 827 (600 residues), 863.4 bits, see alignment E=9.4e-264

Best Hits

Swiss-Prot: 85% identical to CYAA_SALTI: Adenylate cyclase (cyaA) from Salmonella typhi

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 89% identity to ebi:EbC_02100)

MetaCyc: 84% identical to adenylate cyclase (Escherichia coli K-12 substr. MG1655)
Adenylate cyclase. [EC: 4.6.1.1]

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (852 amino acids)

>IAI47_18420 class I adenylate cyclase (Pantoea sp. MT58)
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQRVYSLLPTLLHYQHPQMPGYLEGSVPYG
ISFYTPDENQRQLLADLTGDSDLRHADAPKGEMPITAIYSMGSTSSVGQNSVSDLDIWVC
HQSWLDNEERLNLQRKCTLLQKWCVSMGVEVSFFLIDENRFRHNESGSLGGEDCGSTQHI
LLLDEFYRTAVRMAGKRLLWNMVPGEEEHHYDDYVMSLYAKGVLTPNEWLDLGGLGTLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTQLLAMDIKQRLHDGEIICFGLD
PYCMMLERVTHYLTSVDDQPRLDLVRRCFYLKVCEKLSTEDHHHRTGWRREILSQLVKEW
GWNEEKIAVLDNRAEWKIERVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVL
TRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIHVPPGRANRSGWYLYNQAPDMDSIIS
HQPLEYNRYLNKLVAWAWFNGLLTRKTRLHIKGNEICDLARLQELVNDVSSHFPLRLPSP
TPKALYSPCEIRHLAIIVNLEHDPTAAFRNQVVHFDFRKLDVFSFGQQQQCLIGSIDLLY
RNSWNEVRTLHFSGEQAMIEGLKTILGKMHQDAAPPDTVEVFCYSQHLRGLIRTRVQQLV
SECIELRLSSTRQEPGRFKALRMAGQTWGLFFERMSVSVQKLENAVEFYGAISNNKLHGL
SIKVETNQTPLPPVVNGYASEGIIQFFFENTTDERGFNIYILDETNRVEVYHHCEGSKEE
LVRDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVNTGERFQVIPFRSQTLTQLCTTQPDN
DNSDYQPRYQVH