Protein Info for IAI47_16905 in Pantoea sp. MT58

Annotation: peptidoglycan synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 579 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details PF03717: PBP_dimer" amino acids 66 to 217 (152 residues), 64.5 bits, see alignment E=1.8e-21 PF00905: Transpeptidase" amino acids 258 to 553 (296 residues), 256.4 bits, see alignment E=3.6e-80

Best Hits

Swiss-Prot: 43% identical to FTSI_BUCBP: Peptidoglycan D,D-transpeptidase FtsI (ftsI) from Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

KEGG orthology group: K03587, cell division protein FtsI (penicillin-binding protein 3) [EC: 2.4.1.129] (inferred from 98% identity to pva:Pvag_3703)

Predicted SEED Role

"Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Flagellum in Campylobacter or Peptidoglycan Biosynthesis (EC 2.4.1.129)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129

Use Curated BLAST to search for 2.4.1.129

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (579 amino acids)

>IAI47_16905 peptidoglycan synthase (Pantoea sp. MT58)
MPRIKKLLGKDQIKAPFNPFRFRLICLGVTTCLVVLLARVADLQFLNQPMLEHEADQRSL
RTVTLPTSRGTLLDRNGEALALSVPSRDVIADPQRVLESNPDFTSAKWAYLAAALNTRPE
ELAAQITANPKRRFLYLGRKVELGIAKDIKELKLKGISEVYDDSRFYPMSEASAPLLGIV
GADNVGLNGLEKGFDKVLQGEPGKEVYRQDAAGNIIAMINYQPPTQPPTVQLSIDKYDQY
TLYSKLRDGVLINKADSGAAVLVKIDTGEILAMASYPSFNPNNYEGATPAQMRNSAINDS
YEPGSTVKPLVVMEALERHLVRPDSVIDTTPYSVNGHLIRDVGHWPRLTMTGILQKSSDI
GVSHLALAMPAEALVNTYQAFGLGKPTGLGLTGESVGYFPLHRTRWADIERATFSFGYGL
RVTPLQIAREYATLGSYGVYRPLSITRVTPPVMGRQVANPETVKEVVHMLESDVLPGGTG
LKAAVPGYRLATKTGTAEKMGTSGKYDGGYVNYTAGIAPASHPEVALVVMINHPTAGDHF
GGSVAAPVFGNIMGPVLKHMNIAPDAIYTKPATNTSDKS