Protein Info for IAI47_16860 in Pantoea sp. MT58

Annotation: aspartate carbamoyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02729: OTCace_N
  • amino acids 8 to 148 (141 residues), 161 bits, E=2.2e-51
• TIGR00670: aspartate carbamoyltransferase
  • amino acids 8 to 305 (298 residues), 385.6 bits, E=7.5e-120
• PF00185: OTCace
  • amino acids 156 to 303 (148 residues), 97 bits, E=1.2e-31

Best Hits

Swiss-Prot: 87% identical to PYRB_CITK8: Aspartate carbamoyltransferase (pyrB) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K00609, aspartate carbamoyltransferase catalytic subunit [EC: 2.1.3.2] (inferred from 97% identity to pva:Pvag_3712)

MetaCyc: 86% identical to aspartate carbamoyltransferase catalytic subunit (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Aspartate carbamoyltransferase (EC 2.1.3.2)" in subsystem De Novo Pyrimidine Synthesis (EC 2.1.3.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.1.3.2

Use Curated BLAST to search for 2.1.3.2

Protein Sequence (311 amino acids)

>IAI47_16860 aspartate carbamoyltransferase (Pantoea sp. MT58)
MPNPLYRKHIISINDLSREELELALDTAARLKAHPQPELLKHKVIASCFFEASTRTRLSF
ETAIHRLGASAVGFADGSNTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFS
GGIPILNAGDGANQHPTQTLLDLFTIQETQGRLGQLNVAMVGDLKYGRTVHSLTQALAKF
DGNRFFFIAPDALAMPAYITDMLDEKNIAWSRHDSFEEVMPQLDILYMTRVQKERLDPSE
YANVKAQFILRATDLTTARDNMKVLHPLPRIDEITTDVDKTPYAWYFQQAGNGIYARQAL
LALVLNSELAL