Protein Info for IAI47_16555 in Pantoea sp. MT58

Annotation: type I restriction-modification system endonuclease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1169 PF04313: HSDR_N" amino acids 239 to 391 (153 residues), 28.4 bits, see alignment E=4.6e-10 PF04851: ResIII" amino acids 442 to 621 (180 residues), 124.5 bits, see alignment E=1.2e-39 PF18766: SWI2_SNF2" amino acids 448 to 648 (201 residues), 56.7 bits, see alignment E=8.6e-19 PF00270: DEAD" amino acids 453 to 625 (173 residues), 37.3 bits, see alignment E=7.1e-13 PF00271: Helicase_C" amino acids 715 to 829 (115 residues), 42 bits, see alignment E=3e-14 PF08463: EcoEI_R_C" amino acids 1004 to 1165 (162 residues), 105.3 bits, see alignment E=1.2e-33

Best Hits

Swiss-Prot: 91% identical to T1RK_ECOLI: Type I restriction enzyme EcoKI R protein (hsdR) from Escherichia coli (strain K12)

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 92% identity to ecv:APECO1_2076)

MetaCyc: 91% identical to type I restriction enzyme EcoKI endonuclease subunit (Escherichia coli K-12 substr. MG1655)
Type I site-specific deoxyribonuclease. [EC: 3.1.21.3]

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1169 amino acids)

>IAI47_16555 type I restriction-modification system endonuclease (Pantoea sp. MT58)
MTKSSFEFLKGVNDFTYAIACAAENNYPDDPNTTLVKMRMFGEATAKHLGLLLGIPTCEN
QHDLLRELGKIAFVDDTILSVFHKLRRIGNQAVHEYHNDLDDAQMCLRLGFRLGVWYYRL
VTKNYDFAVPVFALPERGENFYYQEVLTLKQQLEQQTREKAQSQSELAAQQQKLISLNGY
IAILEGKQQETEAQTQARLAALEAQLAEKNAELAKQTEQERKAYQNEITDQAIKRTLDLT
EEESRFLIDAQLRKAGWQADSKALRFSEGARPEPGVSKAIAEWPTGKDETGKQGFADYVL
FVGLKPIAVVEAKRKNIDVPDKLNESYRYSKYFDNAFLRDTLLEEFAAEEVHEAVPAYEI
SWQDTSGEQRFKIPFCYSTNGREYRAAMKTKSGIWYRDVRYTTNMSKALPEWHRPEELLD
MLGSDPQRQNQWFADNPEMSELGLRYYQEDAVRAVETAIVNGQQEILLAMATGTGKTRTA
IALMFRLIQSQRFKRILFLVDRRSLGEQALGAFDDTRINGDTFNSIFDIKGLTDKFPEDS
TKIHVATVQSLVKRTLQSDEPMPVGRYDCIVVDEAHRGYILDKEQTEGELQFRSQLDYVS
AYRRILDHFDAVKVALTATPALHTVQIFGDPVYRYTYRTAVIDGYLIDQDPPIQIITRNA
QEGVYLAQGAQVERINSQGEMINDTLEDEQEFEVASFNRDVIIPGFNRAVCNELTEYLDP
TGLQKTLVFCVTNDHADMVVEELRAAFKKKYPQLEHDAIIKITGDADKDSRKVQTMITRF
NKERLPNIVVTVDLLTTGVDIPSICNIVFLRKVRSRILYEQMKGRATRLCPAVAKTSFKI
FDCVDIYGSLESVDTMRPVVVRPQVELQTLVNEITDSETHKTIEADGRSFAEHSHEQLIA
KLQRIIGLATFNRDRSETVDKQVRRLDELCQDAAGVNFNGFASRLREKGVNWSAEVLNKL
PGFIGRLEKLKADINSLNDAPIFLDIDDEVVSVKSLYGNYDTPQDFLEAFDSLVQRSPNA
QPALQAVINRPRDLTRKGLVELQEWFDRQHFEESSLRKAWKETRNEDIAARLIGHIRRAA
VGDALKPFDERVDHALERIKGENDWNSEQLIWLDRLATALKEKVVLDDDVFKTGNFHRRG
GKTMLQKTFDDDLDNLLDKFSDYIWDEPA