Protein Info for IAI47_15695 in Pantoea sp. MT58
Annotation: cystathionine gamma-synthase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01761, methionine-gamma-lyase [EC: 4.4.1.11] (inferred from 97% identity to pva:Pvag_0171)Predicted SEED Role
"Cystathionine gamma-synthase (EC 2.5.1.48)" in subsystem Methionine Biosynthesis (EC 2.5.1.48)
MetaCyc Pathways
- aspartate superpathway (24/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
- superpathway of branched chain amino acid biosynthesis (17/17 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of S-adenosyl-L-methionine biosynthesis (9/9 steps found)
- superpathway of L-methionine biosynthesis (transsulfuration) (9/9 steps found)
- superpathway of L-homoserine and L-methionine biosynthesis (8/8 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of L-threonine metabolism (15/18 steps found)
- L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
- L-threonine degradation I (6/6 steps found)
- L-methionine biosynthesis I (5/5 steps found)
- L-methionine degradation II (3/3 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- seleno-amino acid detoxification and volatilization III (2/3 steps found)
- dimethyl sulfide biosynthesis from methionine (1/2 steps found)
- seleno-amino acid detoxification and volatilization I (1/2 steps found)
- homocysteine and cysteine interconversion (2/4 steps found)
- superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (6/10 steps found)
- superpathway of L-cysteine biosynthesis (fungi) (2/6 steps found)
- superpathway of seleno-compound metabolism (8/19 steps found)
- hypoglycin biosynthesis (4/14 steps found)
KEGG Metabolic Maps
- Biosynthesis of plant hormones
- Cysteine metabolism
- Methionine metabolism
- Selenoamino acid metabolism
- Sulfur metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.48
Use Curated BLAST to search for 2.5.1.48 or 4.4.1.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (427 amino acids)
>IAI47_15695 cystathionine gamma-synthase family protein (Pantoea sp. MT58) MTSYSGKKTHIGDRPLHPETQMLNYGYDPRLSEGAVKPPVFLTSTFVFDSAEEGRDFFDY VSGRREPPEGKSGGLVYSRFNHPNSEIVEDRLAVYEQAESCSLFSSGMAAISTALLTFAR PGEVILHSQPLYGGTETLLSKTLHNLDIQAVGFSDGNDEVKVRDAAQQAMAQGRVAVILI ETPANPTNSLVNIRLMARIADEIDQQQGSRPIIACDNTLLGPLFQQPLTLGADLSLYSLT KYVGGHSDLIAGAAMGSKALMAKVRALRSAIGTQLDPHSSWMLSRSLETLSLRMEKAFQN AEAVAAFLRDHPKVAKLHWLPYLDAESAEGKTYREQCSGAGSTFSFDITGGQAAAFRFLN ALSLFKQAVSLGGTESLASHPGSTTHSGVPQAVRQRIGITDATVRLSIGIENAGNLIEDI KLALDQV