Protein Info for IAI47_15545 in Pantoea sp. MT58

Annotation: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 274 PF14805: THDPS_N_2" amino acids 3 to 69 (67 residues), 102.3 bits, see alignment E=2e-33 TIGR00965: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase" amino acids 3 to 273 (271 residues), 521.9 bits, see alignment E=1.8e-161 PF14602: Hexapep_2" amino acids 175 to 209 (35 residues), 49.8 bits, see alignment 3.3e-17 PF00132: Hexapep" amino acids 175 to 209 (35 residues), 30.2 bits, see alignment 4e-11

Best Hits

Swiss-Prot: 91% identical to DAPD_CROS8: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD) from Cronobacter sakazakii (strain ATCC BAA-894)

KEGG orthology group: K00674, 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC: 2.3.1.117] (inferred from 99% identity to pva:Pvag_0199)

MetaCyc: 88% identical to tetrahydrodipicolinate succinylase (Escherichia coli K-12 substr. MG1655)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. [EC: 2.3.1.117]

Predicted SEED Role

"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.3.1.117)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.117

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (274 amino acids)

>IAI47_15545 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (Pantoea sp. MT58)
MQQLQSVIESAFERRADITPASVDSETRDAINQVISLLDSGELRVAEKIDGEWVTHQWLK
KAVLLSFRINDNQVMEGSETRFYDKVPMKFAGWDEARFKEAGFRVVPPAAVRQGAYIARN
TVLMPSYVNIGAFVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIED
NCFIGARSEIVEGVIVEAGSVISMGVYIGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPS
KDGSYSLYCAVIVKKVDAKTLGKTGINELLRTID