Protein Info for IAI47_15495 in Pantoea sp. MT58

Annotation: sigma E protease regulator RseP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 56 to 73 (18 residues), see Phobius details amino acids 98 to 120 (23 residues), see Phobius details amino acids 374 to 395 (22 residues), see Phobius details amino acids 424 to 443 (20 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 3 to 448 (446 residues), 536.5 bits, see alignment E=2.3e-165 PF02163: Peptidase_M50" amino acids 10 to 436 (427 residues), 265.6 bits, see alignment E=7.5e-83 PF13180: PDZ_2" amino acids 212 to 285 (74 residues), 39.8 bits, see alignment E=1.2e-13 PF00595: PDZ" amino acids 213 to 276 (64 residues), 35.8 bits, see alignment E=2.1e-12 PF17820: PDZ_6" amino acids 228 to 278 (51 residues), 44.2 bits, see alignment 3.5e-15

Best Hits

Swiss-Prot: 81% identical to RSEP_SALTY: Regulator of sigma E protease (rseP) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 98% identity to pva:Pvag_0209)

MetaCyc: 78% identical to intramembrane zinc metalloprotease RseP (Escherichia coli K-12 substr. MG1655)
3.4.21.-; RXN-18678

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (448 amino acids)

>IAI47_15495 sigma E protease regulator RseP (Pantoea sp. MT58)
MLSIIWSFFAFIVALGVLITVHEFGHFWVARRCGVKVERFSIGFGKALWQRRDRHGTEFV
IALIPLGGYVKMLDERVESVPAELRHQAFNNKAVWQRASIIAAGPVANFIFAIFAYWVVF
IHGVPGVRPVIGEILNGSVAAEAQITPGMELKAVDGIETPDWDAVRMALVGKIGDSSTTL
TVARFGEDATQQKQLDLRNWQFEPDKQDPVVALGIQPRGPQIETTLAEVQANSPASEAGL
QAGDRIVKVDGQPLSQWQTFVTQVRDNPGKSMALEVDRGGESIALTMTPEAKNGSKAGFA
GVIPRIVPLPEEYKTVRQYGAFAAIGEASVKTWQLMKLTVSMLGKLITGDVKLNNLSGPI
SIAQGAGLSAEYGLIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVSER
VQDFSYRIGSILLVLLMGLALFNDFSRL