Protein Info for IAI47_15455 in Pantoea sp. MT58

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1160 TIGR00594: DNA polymerase III, alpha subunit" amino acids 6 to 1031 (1026 residues), 1428.1 bits, see alignment E=0 PF02811: PHP" amino acids 8 to 172 (165 residues), 141.6 bits, see alignment E=9.3e-45 PF07733: DNA_pol3_alpha" amino acids 291 to 558 (268 residues), 348.7 bits, see alignment E=7.4e-108 PF17657: DNA_pol3_finger" amino acids 561 to 733 (173 residues), 222.1 bits, see alignment E=8.1e-70 PF14579: HHH_6" amino acids 808 to 898 (91 residues), 93.4 bits, see alignment 2.5e-30 PF01336: tRNA_anti-codon" amino acids 1000 to 1072 (73 residues), 43.3 bits, see alignment 8.8e-15 PF20914: DNA_pol_IIIA_C" amino acids 1100 to 1151 (52 residues), 95.5 bits, see alignment (E = 3.8e-31)

Best Hits

Swiss-Prot: 91% identical to DPO3A_SALTY: DNA polymerase III subunit alpha (dnaE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 76% identity to vsa:VSAL_I2412)

MetaCyc: 90% identical to DNA polymerase III subunit alpha (Escherichia coli K-12 substr. MG1655)
DNA-directed DNA polymerase. [EC: 2.7.7.7]

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1160 amino acids)

>IAI47_15455 DNA polymerase III subunit alpha (Pantoea sp. MT58)
MAEPRFIHLRVHSDYSMVDGLAKTGPLIKKAAALGMPAIAITDFTNLCGLVKFYGGAHSA
GIKPVIGADFNVASELMGDELTQLTVLASSNTGYQNLTLLISRAYQRGYGVDGPIIDRDW
LIELQEGLILLSGGRRGDVGRSLLRGNNALVSQCLSFYQQHFPDRYYLELIRTGRQDEES
YLHAAVELAIAEGIPVVATNEVCFINAEDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYM
RSEEEMCELFSDIPEALENSVEIAKRCNVTVRLGEYFLPQFPTGDMTTEDYLVVKSREGL
EERLAFLFPDEAERAEKRPEYDERLEIELTVINQMGFPGYFLIVMEFIQWSKDNGVPVGP
GRGSGAGSLVAYALKITDIDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVAD
MYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLEKAFIAEPQ
LPAMYDADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEHGQFPVTQ
FDKNDVEYAGLVKFDFLGLRTLTIIDWALKMINPRREKQGLEPIDIASIPLDDKKSFDML
QRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREA
ISYPDIQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
AKQRSIFRDGAESMGIDGELSMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPA
EFMAAVMTADMDNTEKVVGLVDECWRMGLKVLPPDINSGLYPFHVNDAGEIVYGIGAIKG
VGEGPIEAIIDARNEGGYFRELFDLCARTDTKKINRRVMEKLIMSGAFDRLGPHRAALMS
SLSDALKAADQHAKAEAIGQADMFGVLAEEPEQVEKSYASVTPWPEQVQLDGERETLGLY
LTGHPINQYLKEIERYVGGVRLKDMHPTDRGKITVAAGLVIAARVMVTKRGNRIGICTLD
DRSGRLEVMLFTDALDKYQQLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKY
ARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVNLYYQRADARAKLRFGAAWRISPSD
RLLNDLRSLIGSEQVELEFD