Protein Info for IAI47_15145 in Pantoea sp. MT58

Annotation: beta-Ala-His dipeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 TIGR01893: Xaa-His dipeptidase" amino acids 8 to 480 (473 residues), 594.3 bits, see alignment E=8.6e-183 PF01546: Peptidase_M20" amino acids 72 to 479 (408 residues), 52.3 bits, see alignment E=7.5e-18 PF07687: M20_dimer" amino acids 207 to 291 (85 residues), 41.8 bits, see alignment E=9.4e-15

Best Hits

Swiss-Prot: 79% identical to PEPD_ECOLI: Cytosol non-specific dipeptidase (pepD) from Escherichia coli (strain K12)

KEGG orthology group: K01270, aminoacylhistidine dipeptidase [EC: 3.4.13.3] (inferred from 99% identity to pva:Pvag_0277)

MetaCyc: 79% identical to peptidase D (Escherichia coli K-12 substr. MG1655)
Cytosol nonspecific dipeptidase. [EC: 3.4.13.18]; 3.4.13.18 [EC: 3.4.13.18]; 3.4.13.18 [EC: 3.4.13.18]

Predicted SEED Role

"Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3)" (EC 3.4.13.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.13.18 or 3.4.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (485 amino acids)

>IAI47_15145 beta-Ala-His dipeptidase (Pantoea sp. MT58)
MSELSQLSPQPLWDIFAKICSIPHPSFHEEALANYITGWAKEQGFWCERDQVGNILIRKP
ATAGMENRTPVALQAHLDMVPQKNNDTVHDFTKDPIQPWIDGEWVKARGTTLGADNGIGM
ASALAVLADNSLTHGPLEVLLTMTEETGMDGAFGLQPNWLQAEILINTDSEEEGEIYMGC
AGGIDFVSTLPLTREAVPAEFQTLKLTLKGLRGGHSGADIHMGLGNANKLLARFLAAHAA
ELDLRLLAFSGGTLRNAIPREAFATVAVESHKADALKSAAAQFLSAIKNEHGIKEPNIAL
VTEPLAHQGDALSTDSRDRFLNLLNSTPNGVIRNSDVAKGVVETSLNIGVVTMEADHAEI
NCLIRSLIDTGRDYVVQMLTSLGQLAGAQTKAKGGYPGWQPDADSAIMALTRQTYIALFD
KTPNIQVIHAGLECGLFKKPYPDMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTTLLN
VVPEK