Protein Info for IAI47_15115 in Pantoea sp. MT58

Annotation: glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 279 (277 residues), 43.4 bits, E=8.8e-16
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 9 to 406 (398 residues), 607.5 bits, E=4.9e-187

Best Hits

Swiss-Prot: 81% identical to PROA_ERWT9: Gamma-glutamyl phosphate reductase (proA) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 98% identity to pva:Pvag_0283)

MetaCyc: 74% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (2/3 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)
• L-N^δ-acetylornithine biosynthesis (3/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (417 amino acids)

>IAI47_15115 glutamate-5-semialdehyde dehydrogenase (Pantoea sp. MT58)
MLEEMGKAARAAAYTVADLSTAEKNDVLMTIADRLEAESADILAANELDLADARQNGMSA
ALLDRLTLNPQRLSSIASDVRQVCQLADPVGQLIDGGQLDSGLRIERRRVPLGVVAVIYE
ARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVRVIQNALKQHGLPVAIVQAIENPD
RELVNQLLKLDRYVDMLIPRGGAGLHKLCRENSTIPVITGGIGVCHIYIDETMEIEPALD
VIVNAKKQRPSACNSLETLLVDQAMAERFLPAFSARMAQEGIALHADSNVLAQLQHGPAP
VKPVNPQQYNDEWLSLDLNVKLVADMDEAIDHIRTHGTQHSDAILTRNTRNAARFVRQVD
SSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIAWGDDTLRP