Protein Info for IAI47_14830 in Pantoea sp. MT58

Annotation: proline-specific permease ProY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 16 to 34 (19 residues), see Phobius details amino acids 40 to 61 (22 residues), see Phobius details amino acids 94 to 117 (24 residues), see Phobius details amino acids 124 to 142 (19 residues), see Phobius details amino acids 154 to 174 (21 residues), see Phobius details amino acids 193 to 218 (26 residues), see Phobius details amino acids 239 to 259 (21 residues), see Phobius details amino acids 277 to 298 (22 residues), see Phobius details amino acids 330 to 350 (21 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details amino acids 400 to 421 (22 residues), see Phobius details amino acids 427 to 446 (20 residues), see Phobius details PF03845: Spore_permease" amino acids 11 to 281 (271 residues), 24.5 bits, see alignment E=1.7e-09 PF00324: AA_permease" amino acids 15 to 449 (435 residues), 398.2 bits, see alignment E=7.4e-123 PF13520: AA_permease_2" amino acids 16 to 440 (425 residues), 128.2 bits, see alignment E=6.6e-41

Best Hits

Swiss-Prot: 85% identical to PROY_ECO57: Proline-specific permease ProY (proY) from Escherichia coli O157:H7

KEGG orthology group: K03293, amino acid transporter, AAT family (inferred from 99% identity to pva:Pvag_0341)

MetaCyc: 49% identical to threonine/serine:H+ symporter ThrP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-71; TRANS-RXN-72

Predicted SEED Role

"Proline-specific permease proY" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>IAI47_14830 proline-specific permease ProY (Pantoea sp. MT58)
MQETNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGAVAYIIMR
ALGEMSVNNPQASSFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPE
VPHWIWVLSVVLIIGAVNLMSVKVFGEVEFWFSFFKVATIIVMILAGFGMIIWGIGNGGQ
PTGIHNLWTNGGFFAHGVVGMLLSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
WRILVFYVGTLFVIMSIYPWNQVGTSGSPFVLTFQHLGIAAAASILNFVVLTASLSAINS
DVFGVGRMLHGMAQQGHAPKVFMKVSSRGIPWVTVVVMMFAMLIAVYLNYLMPEKVFLVI
ASLATFATVWVWIMILLSQIAFRRKIGKEAASKLKFALPGGSWTAGVGVAFLCFIIGLIG
YFPDTRISLYVGMVWIVVLLLGYKLVRKTR