Protein Info for IAI47_14740 in Pantoea sp. MT58

Annotation: 1-deoxy-D-xylulose-5-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00204: 1-deoxy-D-xylulose-5-phosphate synthase
  • amino acids 12 to 620 (609 residues), 1011.2 bits, E=0
• PF13292: DXP_synthase_N
  • amino acids 14 to 282 (269 residues), 389.6 bits, E=1.5e-120
• PF02779: Transket_pyr
  • amino acids 320 to 479 (160 residues), 159.6 bits, E=1.2e-50
• PF02780: Transketolase_C
  • amino acids 495 to 611 (117 residues), 94.6 bits, E=8.6e-31

Best Hits

Swiss-Prot: 87% identical to DXS_ERWT9: 1-deoxy-D-xylulose-5-phosphate synthase (dxs) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K01662, 1-deoxy-D-xylulose-5-phosphate synthase [EC: 2.2.1.7] (inferred from 99% identity to pva:Pvag_0359)

MetaCyc: 82% identical to 1-deoxy-D-xylulose-5-phosphate synthase (Escherichia coli K-12 substr. MG1655)
1-deoxy-D-xylulose-5-phosphate synthase. [EC: 2.2.1.7]

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7)" in subsystem Isoprenoid Biosynthesis or Pyridoxin (Vitamin B6) Biosynthesis or Thiamin biosynthesis (EC 2.2.1.7)

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (12/12 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (12/12 steps found)
• taxadiene biosynthesis (engineered) (12/13 steps found)
• methylerythritol phosphate pathway I (9/9 steps found)
• methylerythritol phosphate pathway II (9/9 steps found)
• pyridoxal 5'-phosphate biosynthesis I (7/7 steps found)
• isoprene biosynthesis I (9/10 steps found)
• superpathway of thiamine diphosphate biosynthesis II (9/11 steps found)
• superpathway of thiamine diphosphate biosynthesis I (8/10 steps found)
• thiazole component of thiamine diphosphate biosynthesis II (5/7 steps found)
• thiazole component of thiamine diphosphate biosynthesis I (4/6 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.2.1.7

Protein Sequence (621 amino acids)

>IAI47_14740 1-deoxy-D-xylulose-5-phosphate synthase (Pantoea sp. MT58)
MSFDIAKYPTLALANTVQELRALPKEKLPALCDELRQYLLDSVSRSSGHFASGLGVVELT
VALHYVYNTPFDHLVWDVGHQAYPHKILTGRRDRIGTIRQKNGVHPFPWRGESEYDVLSV
GHSSTSISAGLGMAAAAEREGQGRRTACIIGDGAITAGMAFEAMNHAGDIKPDMLVILND
NEMSISENVGALNNRLAQILSGKTYARLREGSKRVLTSLPPIKELVRRTEEHLKGMVVPG
TLFEELGFNYIGPVDGHDVLTLVNTLSNMRSLKGPQFLHIMTKKGKGYAPAEEDPIAWHA
VPKFDPAIGELPKSAEGLPSYSKIFGNWLCEMAADDPKLMAITPAMREGSGMVAFSREFP
KQYFDVAIAEQHAVTFAAGMAIGGYKPIVAIYSTFLQRAYDQLIHDVAIQKLPVLFAIDR
GGIVGADGQTHQGAFDLAYLRCVPDMVIMTPSDENECRQMLYTGYHYQAGPSAVRYPRGT
GVGTPLAPLQSLPLGKAVVKRQGEKLAILNFGTLLPEAAATAEALNATLVDMRFVKPLDE
ALIAELAATHDSLITLEEGAIKGGAGSGVNEFIMAKRLAVPVLNIGLPDEFIPQGTQDEV
RHDYLLDAEGIQQQIARWLAQ