Protein Info for IAI47_14635 in Pantoea sp. MT58

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 165 (165 residues), 159.6 bits, see alignment E=1.5e-50 PF13623: SurA_N_2" amino acids 2 to 141 (140 residues), 110.4 bits, see alignment E=1.8e-35 PF13145: Rotamase_2" amino acids 248 to 368 (121 residues), 84.7 bits, see alignment E=2.3e-27 PF13616: Rotamase_3" amino acids 273 to 355 (83 residues), 50.3 bits, see alignment E=8.7e-17 PF00639: Rotamase" amino acids 275 to 355 (81 residues), 51.5 bits, see alignment E=4.3e-17

Best Hits

Swiss-Prot: 67% identical to PPID_ECOL6: Peptidyl-prolyl cis-trans isomerase D (ppiD) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 97% identity to pva:Pvag_0381)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>IAI47_14635 peptidylprolyl isomerase (Pantoea sp. MT58)
MMDNLRAASNNVVLKIILGLIMVSFVLTGVGNYLIGGNNDYAAKVNGQEISRGQLEQAFN
SERSRQQQMLGDQFSQLASNDGYMQQIRQQALSQLIDQALLDSYIKDLHLSISDDQVKQA
IFNQQAFQTNGKFDNAKYLALIGNMGFSADQYAEALRKQLSNQQLINAVANTDFTLKGEA
SKLVDLVSQQRDIRQATLDVNALAAKQTVTDDEISQYYQQHKTSFMAPEQFRVSYILMDA
ASMQQDASEADIQAWYDQHKADYTQPQRTRYSVIQTKTEADANAVLAQLKGGASFADVAK
AKSIDPISARKGGDMGWLEPSTTPDELKNAGLTQKGQMSGVIKSSVGFLVVRLDDIQPEQ
VKPLNDVRSAIAAKVKQEKGVDAFYKLQQKVSEAASNDNESLAGAEQASGLKAKETGWFS
QDTLPDALNFDAVKQAIFNGGLVGQNGAPGNNSDIITVDGDRAFVLRISEHKPEAVKPLD
QVKAQITDTLKHDKATQQAKAQADKLLTDLKAGKQDALTAAGLTLSASKTVDRNAQDPVA
QAAFNLPQPAENKPSWGVSEDMQGNVVLVAVDKVKTGSMPQAQIDEMVKGVTQNNAQLTF
EALLQNLRKEAKIKYGAAAQMQ