Protein Info for IAI47_14620 in Pantoea sp. MT58

Annotation: 7-cyano-7-deazaguanine synthase QueC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06508: QueC
  • amino acids 3 to 212 (210 residues), 273.4 bits, E=1.2e-85
• TIGR00364: queuosine biosynthesis protein QueC
  • amino acids 4 to 206 (203 residues), 286.4 bits, E=5.1e-90
• PF00733: Asn_synthase
  • amino acids 6 to 60 (55 residues), 22.1 bits, E=1.1e-08

Best Hits

Swiss-Prot: 84% identical to QUEC_CITK8: 7-cyano-7-deazaguanine synthase (queC) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K06920, queuosine biosynthesis protein QueC (inferred from 95% identity to pva:Pvag_0384)

MetaCyc: 84% identical to 7-cyano-7-deazaguanine synthase (Escherichia coli K-12 substr. MG1655)
RXN-12093 [EC: 6.3.4.20]

Predicted SEED Role

"Queuosine Biosynthesis QueC ATPase" in subsystem Queuosine-Archaeosine Biosynthesis

MetaCyc Pathways

• preQ₀ biosynthesis (3/4 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.20

Protein Sequence (231 amino acids)

>IAI47_14620 7-cyano-7-deazaguanine synthase QueC (Pantoea sp. MT58)
MKRAVVVFSGGQDSTTCLIQALEQYDEVHCVTFDYGQRHREEIEVARDLASKLGARAHKV
LDVTMLNELAVSSLTRDNIPVPAYNPEASGLPSTFVPGRNILFLTLASVYAYQVEAEAVI
TGVCETDFSGYPDCRDEFVKALNHAVSLGMAREVRFETPLMWLNKAETWALADYWQQLSL
VREQTLTCYNGVKGDGCGECAACNLRANGLQGYLNDRDSVMAAMKAKSGLS