Protein Info for IAI47_14400 in Pantoea sp. MT58

Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 837 transmembrane" amino acids 187 to 207 (21 residues), see Phobius details amino acids 219 to 240 (22 residues), see Phobius details amino acids 252 to 274 (23 residues), see Phobius details amino acids 286 to 304 (19 residues), see Phobius details amino acids 438 to 460 (23 residues), see Phobius details amino acids 466 to 488 (23 residues), see Phobius details amino acids 780 to 799 (20 residues), see Phobius details amino acids 805 to 826 (22 residues), see Phobius details PF00403: HMA" amino acids 7 to 62 (56 residues), 37.1 bits, see alignment 8.8e-13 amino acids 106 to 161 (56 residues), 56 bits, see alignment 1.1e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 236 to 829 (594 residues), 615.5 bits, see alignment E=2.1e-188 TIGR01525: heavy metal translocating P-type ATPase" amino acids 254 to 829 (576 residues), 604.8 bits, see alignment E=3.7e-185 TIGR01512: cadmium-translocating P-type ATPase" amino acids 289 to 830 (542 residues), 383.3 bits, see alignment E=3.5e-118 TIGR01494: HAD ATPase, P-type, family IC" amino acids 293 to 802 (510 residues), 294.8 bits, see alignment E=1.9e-91 PF00122: E1-E2_ATPase" amino acids 322 to 502 (181 residues), 174.3 bits, see alignment E=4.7e-55 PF00702: Hydrolase" amino acids 519 to 733 (215 residues), 133.9 bits, see alignment E=2.4e-42 PF12710: HAD" amino acids 620 to 730 (111 residues), 31.1 bits, see alignment E=8.3e-11 PF08282: Hydrolase_3" amino acids 708 to 766 (59 residues), 21.4 bits, see alignment 4.7e-08

Best Hits

Swiss-Prot: 67% identical to COPA_ECO57: Copper-exporting P-type ATPase (copA) from Escherichia coli O157:H7

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 70% identity to eay:EAM_1044)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (837 amino acids)

>IAI47_14400 copper-exporting P-type ATPase CopA (Pantoea sp. MT58)
MSHTISLALDGLSCGHCVKRVKEALEQRDDVDLAEVTQQEAQVSGQADAAALIATVEQAG
YHATLKTADASPKSEPLTASEPPPEALTTETASHPAEKALPAHMLLIEGMTCASCVSRVE
KALQQVTGVSQARVNLGERSALVLGNADPHQLVAAVDAAGYGAQVVDDEQERREKQQHSA
RRAMRRFSWQAAVALAFGVPLMIWGMVGNNMMLTDSNHTTWLALGVVTLLIMVVTGSHFY
RSAWRSLRNGSATMDTLVALGTGAAWVYSFSVVLWPDFFPPQARHLYFEASVMILGLINL
GHALEQRARQRSSKALERLLDLTPAQARLVDQQGDRLIPVSDVQPGMTLRLVTGDRVPVD
GEIVTGEAWFDEAMLTGEAVPQSKNPGAAIFAGTLVQDGSVEFTARATGNHTTLSRIIRL
VRQAQSSKPDLGRLADRISAVFVPVVVLIALLSGAVWYLFGPQPHIAYMLVIATTVLIIA
CPCALGLATPMSIIAGVGRAAELGVLVRDADALQRASQIDTLVFDKTGTLTAGKPQVSEV
LVWGDASRESVLATAAALEFSSGHPLAKAIVAEAKLTQPPQLAQFRTIRGKGVSGILDGR
TLLLGNAALLHDSGIDYQVAEAEIARLTQQGATPVLLAEQGQLTGLIALRDQLRPESGAA
LKRLHQQGYRLIMLTGDHENTARAIAAEAGIDEVIAGVLPDGKAAAIEALQQQGRRVAMV
GDGINDAPALAQAEVGIAMGGGSDVAVETAGITLMRADLNSVADALALASATLRNIRQNL
FGAFIYNSIGIPVAAGVLYPLTGTLLSPIVAGAAMALSSITVVSNANRLLRYQPPRQ