Protein Info for IAI47_13635 in Pantoea sp. MT58

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 24 to 341 (318 residues), 401.5 bits, E=1.2e-124
• PF02445: NadA
  • amino acids 31 to 339 (309 residues), 349.6 bits, E=6.6e-109

Best Hits

Swiss-Prot: 87% identical to NADA_SALCH: Quinolinate synthase A (nadA) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 98% identity to pva:Pvag_0569)

MetaCyc: 85% identical to quinolinate synthase (Escherichia coli K-12 substr. MG1655)
Quinolinate synthase. [EC: 2.5.1.72]

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• NAD de novo biosynthesis I (5/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (5/6 steps found)
• NAD de novo biosynthesis III (4/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (353 amino acids)

>IAI47_13635 quinolinate synthase NadA (Pantoea sp. MT58)
MSVMFDPESAVYPFPPKPARLSDDEKTFYREKIKALLKARNAVMVAHYYTDPEIQALAEE
TGGCVSDSLEMARFGSNHSATTLLVAGVRFMGETAKILSPEKTVLMPTLQAECSLDLGCP
IEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRH
LGRYVTRMSGADVLCWQGACIVHDEFKTQALQRMKALYPDAAVLVHPESPQAIVELADAV
GSTSQLIQAAKSLPHPQMIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWM
AMNGLKAIAEALESGGVEHEIQVDETLREAALLPLNRMLSFAAELKLNVKGNA