Protein Info for IAI47_13545 in Pantoea sp. MT58

Annotation: 6-phosphogluconolactonase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF10282: Lactonase
  • amino acids 7 to 327 (321 residues), 300.5 bits, E=8.8e-94

Best Hits

Swiss-Prot: 72% identical to 6PGL_ERWT9: 6-phosphogluconolactonase (pgl) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K07404, 6-phosphogluconolactonase [EC: 3.1.1.31] (inferred from 98% identity to pva:Pvag_0586)

MetaCyc: 69% identical to 6-phosphogluconolactonase (Escherichia coli K-12 substr. MG1655)
6-phosphogluconolactonase. [EC: 3.1.1.31]

Predicted SEED Role

"6-phosphogluconolactonase (EC 3.1.1.31)" in subsystem Entner-Doudoroff Pathway or Pentose phosphate pathway (EC 3.1.1.31)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• heterolactic fermentation (16/18 steps found)
• pentose phosphate pathway (8/8 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)
• formaldehyde oxidation I (4/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.31

Use Curated BLAST to search for 3.1.1.31

Protein Sequence (333 amino acids)

>IAI47_13545 6-phosphogluconolactonase (Pantoea sp. MT58)
MKQVVYTASPESQQIHVWQMNDEGALTLLQVTDVAGQVQPMVVSPKRDFLYVGVRPNFRV
LAFKIAADGTLTEAGQAPLPGSPTHISTDREGRFLFCGSYNDACVSVSPIGDDGIPQAPL
QVINGLDGCHSANIDTDNKTLYVPALKQDRICLFSLGADGQLTPRKQAQVTTVEGAGPRH
MQFHPGGQFAYCVNELDSTVEVWALNTGEGEAESVQTLDMMPPDFNGTRWAADIHLTPDG
RFLYACDRTSSTLAVFSVSELGDELTLEGFQPTETQPRGFNIDHSGRYLVAAGQKSHHIE
VYAISEPKGLLQPLGRYAVGQGPMWVVIHQLQA