Protein Info for IAI47_13525 in Pantoea sp. MT58

Annotation: 8-amino-7-oxononanoate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00858: 8-amino-7-oxononanoate synthase
  • amino acids 20 to 379 (360 residues), 432.8 bits, E=4.3e-134
• PF00155: Aminotran_1_2
  • amino acids 40 to 378 (339 residues), 198.6 bits, E=9.2e-63

Best Hits

Swiss-Prot: 70% identical to BIOF_YERPB: 8-amino-7-oxononanoate synthase (bioF) from Yersinia pseudotuberculosis serotype IB (strain PB1/+)

KEGG orthology group: K00652, 8-amino-7-oxononanoate synthase [EC: 2.3.1.47] (inferred from 92% identity to pva:Pvag_0590)

MetaCyc: 63% identical to 8-amino-7-oxononanoate synthase (Escherichia coli K-12 substr. MG1655)
8-amino-7-oxononanoate synthase. [EC: 2.3.1.47]; 2.3.1.47 [EC: 2.3.1.47]

Predicted SEED Role

"8-amino-7-oxononanoate synthase (EC 2.3.1.47)" in subsystem Biotin biosynthesis (EC 2.3.1.47)

MetaCyc Pathways

• biotin biosynthesis I (14/15 steps found)
• 8-amino-7-oxononanoate biosynthesis I (10/11 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (4/5 steps found)
• biotin biosynthesis II (4/6 steps found)
• 8-amino-7-oxononanoate biosynthesis II (1/2 steps found)
• 8-amino-7-oxononanoate biosynthesis III (1/2 steps found)

KEGG Metabolic Maps

• Biotin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.47

Protein Sequence (383 amino acids)

>IAI47_13525 8-amino-7-oxononanoate synthase (Pantoea sp. MT58)
MSWQQRLRQGLAQRRAADGWRQRRVIDEQSTRTLQSGGRNYLHFSSNDYLGLTRHPAVIA
GWQQGAALAGAGAGASGHVTGYHRQHADLEAQLADWLGYDCALLFISGFAANQAVIHLLG
EKNDRILADKLSHASLLDAASHSPAQLRRFSHNAPESLAARLALPCEGETLVVTEGIFSM
DGDSAPLAALAQQTRQAEGWLLVDDAHGIGVVGEQGRGSCCLQGVKPELLVVTFGKAFGV
SGAALLCDAETADYFLQFSRHLICSTAMPAAQAVALQAALQVIQQGDALRQQLQQNIRHF
RRGAASLPWQLMNSESAIQPLLVGENSDAMTLSQRLAEAGCWVSAIRPPTVPPGTARLRI
TLTAAHRPEDIDRLLEVLHDAAD