Protein Info for IAI47_13270 in Pantoea sp. MT58

Annotation: histidine utilization repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 251 TIGR02018: histidine utilization repressor" amino acids 20 to 247 (228 residues), 333.2 bits, see alignment E=3.4e-104 PF00392: GntR" amino acids 22 to 84 (63 residues), 71.3 bits, see alignment E=6.5e-24 PF08220: HTH_DeoR" amino acids 48 to 79 (32 residues), 21.4 bits, see alignment 2.6e-08 PF07702: UTRA" amino acids 105 to 242 (138 residues), 120.9 bits, see alignment E=5.8e-39

Best Hits

Swiss-Prot: 65% identical to HUTC_PSEAE: Histidine utilization repressor (hutC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 97% identity to pva:Pvag_0646)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (251 amino acids)

>IAI47_13270 histidine utilization repressor (Pantoea sp. MT58)
MVEHTALAQLAAAMSDEPAPIYQRVKQAIVSQIREGLWKANQRVPSESELVNELGVSRMT
INRALRELTSEGFLVRMQGVGTFVAEMKGYTAMLEVHNIADEIAQRGHQHSAKILTLGQN
KADPEQAAVLGLTTGQTLFHSLIVHYENDLPVQLEDRLVNPLVAPDYLTQDYEKMTPYTY
LMRVAPLTAGEHIVEAVLPDARQRKHLSLDEHEPCLLIRRQTWSDMKIVTYARLLYPGSR
YKLLGRFRGHG