Protein Info for IAI47_12770 in Pantoea sp. MT58

Annotation: MBL fold metallo-hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00753: Lactamase_B
  • amino acids 9 to 192 (184 residues), 131.9 bits, E=1.5e-42

Best Hits

Swiss-Prot: 71% identical to GLO22_ECOLI: Hydroxyacylglutathione hydrolase GloC (gloC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 95% identity to pva:Pvag_0753)

MetaCyc: 71% identical to hydroxyacylglutathione hydrolase GloC (Escherichia coli K-12 substr. MG1655)
Hydroxyacylglutathione hydrolase. [EC: 3.1.2.6]

Predicted SEED Role

"Hypothetical metal-binding enzyme, YcbL homolog"

MetaCyc Pathways

• methylglyoxal degradation I (2/3 steps found)
• methylglyoxal degradation VIII (2/3 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.2.6

Use Curated BLAST to search for 3.1.2.6

Protein Sequence (209 amino acids)

>IAI47_12770 MBL fold metallo-hydrolase (Pantoea sp. MT58)
MNYHIIPVTAFAQNCSVIWCDSTREAALVDPGGDAELVKQTLEQLGLKPAQILLTHGHLD
HVGAAVELAAFWQIPIIGPQKRDAFWLEALPTQSRMFGLDECAPFTPDRWLEEGESVQVG
LITLEVLHCPGHSPGHVVFFDRQGRLLISGDVIFNGGVGRTDFPQGDHQQLINAIRTKLL
PLGDDVTFLPGHGPISTLGHERVSNPFLQ