Protein Info for IAI47_12655 in Pantoea sp. MT58

Annotation: Lon protease family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 PF13654: AAA_32" amino acids 172 to 263 (92 residues), 52.4 bits, see alignment E=5.6e-18 PF05362: Lon_C" amino acids 471 to 547 (77 residues), 36.3 bits, see alignment E=4.7e-13

Best Hits

KEGG orthology group: K04770, Lon-like ATP-dependent protease [EC: 3.4.21.-] (inferred from 95% identity to pva:Pvag_0777)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-, 3.4.21.53

Use Curated BLAST to search for 3.4.21.- or 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (623 amino acids)

>IAI47_12655 Lon protease family protein (Pantoea sp. MT58)
MQQRKTCCHHHIFNRKSAVLNKGDSCIISLFLIQTNAIILTSTQLTWQTLQPDSAQYQSV
FSRIADEETDALATVQPRLLNALAHLHHQTQGFPLLLVRSQENRDYLAFIAQAAQRVMAD
STTLYGGDYHIMADNVTLQPPSDPQRPFTSQGGIHFAEWIEMEQLFGCVRQYKDRIQLEP
GLIHRANGGTLVLSLQSLMTQPILWLRLKKCIEQGYVEWTSQDERQPLPVSIPPLPLSLN
LVLCGERETLADFQELDPEAHEMAIYTEFEENIQILDEDDMLAWCRWNAELAQQAGLPLP
EEDFWPELIKEGVRYSGDQDTLPLCPRWLQRQMRESALMGDEQLNAEALRDALEARLWRE
NYLNERMRDEILLRQILIETEGEVVGQINGLSVVEFPGHPRAWGDTSRITCVVHPGDGEF
MDIERKAELGGNIHAKGMMIMQAYLTAELELDQQLPFSASMVFEQSYSEVDGDSASLAEL
CALISALANQPINQQIAVTGSVDQFGNVQPVGGLNEKIEGFFDICHQRELTGQQGVIIPA
CNVRHLSLNQAVVTAVEQGRFHIWAIDQAEEALPLLTGKIWSTEDGLGDCLLNTIQERIS
LFNQPDGPQRPWALRWLNWFNHR