Protein Info for IAI47_12505 in Pantoea sp. MT58

Annotation: HTH-type transcriptional regulator RutR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 211 transmembrane" amino acids 21 to 35 (15 residues), see Phobius details PF00440: TetR_N" amino acids 22 to 68 (47 residues), 46.4 bits, see alignment 2.8e-16 PF08362: TetR_C_3" amino acids 69 to 210 (142 residues), 195.7 bits, see alignment E=3.8e-62

Best Hits

Swiss-Prot: 70% identical to RUTR_ECO57: HTH-type transcriptional regulator RutR (rutR) from Escherichia coli O157:H7

KEGG orthology group: K09017, TetR/AcrR family transcriptional regulator (inferred from 98% identity to pva:Pvag_0806)

Predicted SEED Role

"Transcriptional regulator RutR of pyrimidine catabolism (TetR family)" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (211 amino acids)

>IAI47_12505 HTH-type transcriptional regulator RutR (Pantoea sp. MT58)
MNTDEKKPTRRSRAVAAKRAAILEAALTFFSQFGIHGTSLDKVAELADVSKTNLLYYFPS
KEVLYVAVLKQILDVWLAPLRALAHDQDPLVAIRRYIRLKLEVSRDHPQASRLFCLEMLQ
GAPLLKGELAGDLKQLVDDKAAIIECWIDEGWLAGVQPQHLIFMLWATTQHYADFATQVE
AVTGQTLSDPAFFDQAVDNVQRMIIEGIRVR