Protein Info for IAI47_12000 in Pantoea sp. MT58

Annotation: thiamine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01636: APH
  • amino acids 30 to 212 (183 residues), 53.7 bits, E=2.7e-18

Best Hits

KEGG orthology group: K07251, thiamine kinase [EC: 2.7.1.89] (inferred from 84% identity to pva:Pvag_0908)

Predicted SEED Role

"Thiamine kinase (EC 2.7.1.89) @ Adenosylcobinamide kinase (EC 2.7.1.156)" (EC 2.7.1.156, EC 2.7.1.89)

MetaCyc Pathways

• thiamine diphosphate salvage I (2/2 steps found)
• adenosylcobinamide-GDP salvage from cobinamide I (4/5 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide I (4/8 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism
• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.156 or 2.7.1.89

Protein Sequence (260 amino acids)

>IAI47_12000 thiamine kinase (Pantoea sp. MT58)
MIEQVTGEPDKALIMPLAGLTGHSQKIVSPSGTFIVRATPQPAIPFVDRQREFRLLRKLR
TTGLAPQPVASHPQGIILTWCAGEALDAQRFGEQRPQIVALLKQLHQQPLTGYQLSMLSL
LWDYWQLTPQRHHRWLRALRRLTQQGEPRPLRLAPLHMDLHAGNVIQGPEGLRLIDWEYA
ADGDVALELAAVCASDPQHDADWLAEYAAAMQLPLPALVQQVRRWQPWLRLLMASWYQLR
ASQSENETLHQLARQSWEQI