Protein Info for IAI47_11975 in Pantoea sp. MT58

Annotation: transcription-repair coupling factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1147 PF17757: UvrB_inter" amino acids 129 to 217 (89 residues), 96 bits, see alignment 4.8e-31 TIGR00580: transcription-repair coupling factor" amino acids 145 to 1079 (935 residues), 1186.8 bits, see alignment E=0 PF21132: MFD_D3" amino acids 377 to 449 (73 residues), 102.7 bits, see alignment 3.4e-33 PF02559: CarD_TRCF_RID" amino acids 477 to 532 (56 residues), 68.7 bits, see alignment 1.5e-22 PF04851: ResIII" amino acids 600 to 758 (159 residues), 49.8 bits, see alignment E=1.5e-16 PF00270: DEAD" amino acids 602 to 764 (163 residues), 97.8 bits, see alignment E=2.4e-31 PF00271: Helicase_C" amino acids 802 to 906 (105 residues), 69.9 bits, see alignment E=8.4e-23 PF03461: TRCF" amino acids 1006 to 1098 (93 residues), 98.4 bits, see alignment E=9.8e-32

Best Hits

Swiss-Prot: 82% identical to MFD_ECOLI: Transcription-repair-coupling factor (mfd) from Escherichia coli (strain K12)

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 64% identity to aap:NT05HA_0196)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1147 amino acids)

>IAI47_11975 transcription-repair coupling factor (Pantoea sp. MT58)
MPEQTRYTLPVKSGDHRQLGQIIGAAHAVECASITEHHAGPVLMITPDTQTALRLLDEIR
QFTDLPVTHLADWETLPYDSFSPHQDIISARLSTLYQLPVMQRGMLIMPVNTLMQRVCPH
SFLHGHALVMKQGQKLSRDRLRDQLEQAGYRHVDQVMEHGEYATRGALLDLFPMGSDQPY
RIDFFDDEIDSLRLFDVDSQRTLEAVTEINLLPAHEFPSDKAAIELFRSRWREIFDVRRE
SEHVYQQVSKGTLPAGIEYWQPLFFEQPLPSLFSYLPDNTLIVNCGDLEGSARRFWQDAE
ARYENRRVDPMRPLLEPVTLWLRPDALMGELKAWPRIQMTNEVLPDKAANTNLGYTPLPD
LAVQAQAKAPLDHLRQFIETFSGAVVFSVESEGRRETLQELLARIKLRPQPVHRFDETVD
DRFSLMIGASERGFIDTQGNRALICESDLLGERVSRRRQDTRRTINPDILIRNLAELSPG
QPVVHLEHGVGRYIGLTTLEAGGIQAEYLMLSYANDAKLYVPVSSLHLISRYAGGADDNA
PLHKLGSDAWSRARQKAAEKVRDVAAELLDIYAQRAAKSGFAFKHNREQYQLFCESFPFE
TTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAIENHKQVAVLVPTTL
LAQQHYDNFRDRFANWPVRIEMLSRFRTAKEQAQVLEQASDGKIDILIGTHKLLMSDLKW
HDLGLLIVDEEHRFGVRHKERIKAMRADVDILTLTATPIPRTLNMAMSGMRDLSIIATPP
ARRLAVKTFVREFDDLVIREAILREVLRGGQVYYLYNDVENIEKAAQRLSELVPEARVAI
GHGQMRERDLERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLR
GRVGRSHHQAYAWLLTPHPKSMTADAHKRLEAIASLEDLGAGFALATHDLEIRGAGELLG
DEQSGQMETLGFTLYMELLENAVDALKAGREPSLEDLTSNQTEVELRMPALLPETFIPDV
STRLSLYKRIASAEVEEELQELKVEMIDRFGLLPDPARNLLDVAIIRLKARAVGLRKIEA
SDKGGYFDFAPKNNVDPAWLIGLLQKEPQQWKLDGPTRLRFTRELSERKIRMEWVQGFVS
QLAEHQA