Protein Info for IAI47_11245 in Pantoea sp. MT58

Annotation: sodium-potassium/proton antiporter ChaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 35 to 56 (22 residues), see Phobius details amino acids 69 to 91 (23 residues), see Phobius details amino acids 104 to 124 (21 residues), see Phobius details amino acids 138 to 158 (21 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 218 to 235 (18 residues), see Phobius details amino acids 255 to 276 (22 residues), see Phobius details amino acids 286 to 309 (24 residues), see Phobius details amino acids 320 to 337 (18 residues), see Phobius details amino acids 344 to 362 (19 residues), see Phobius details TIGR00846: calcium/proton exchanger" amino acids 6 to 361 (356 residues), 357.3 bits, see alignment E=4e-111 PF01699: Na_Ca_ex" amino acids 37 to 187 (151 residues), 55.2 bits, see alignment E=4.2e-19 amino acids 220 to 361 (142 residues), 40.6 bits, see alignment E=1.3e-14

Best Hits

Swiss-Prot: 82% identical to CHAA_ECOLI: Sodium-potassium/proton antiporter ChaA (chaA) from Escherichia coli (strain K12)

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 98% identity to pva:Pvag_1079)

MetaCyc: 82% identical to Na+/K+:H+ antiporter ChaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-101; TRANS-RXN-42

Predicted SEED Role

"Calcium/proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (363 amino acids)

>IAI47_11245 sodium-potassium/proton antiporter ChaA (Pantoea sp. MT58)
MPSHEKTRHKEFSLIFPLITLGILYFFGANTAFPVVVGINLVALIAILSSAFSVVRHADV
LAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPGLMRDTLYSIVMIVTGGLVGFAL
LLGGNKFATQYVNLAGVKQYLIAIFPLAILVLVFPNALPGGNFSVTQALLIAAISAAMYG
VFLLIQTKTHQSLFVYEHEDESDDGDPHHGKPSAHSSVWHTIWLIVHLIAVIAVTKMNAN
TLESLLTDLNAPAQFTGFLVALLILSPEGLGAIKAVLMNQVQRAMNLFFGSVLATISLTV
PAVTIIATLTGQELIFGLEPPQMVIMMASLILCQLSFSTGRTNVLNGAAHLALFIGYLMT
IML