Protein Info for IAI47_11020 in Pantoea sp. MT58

Annotation: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01832: 2-deoxy-D-gluconate 3-dehydrogenase
  • amino acids 6 to 253 (248 residues), 432.7 bits, E=2e-134
• PF00106: adh_short
  • amino acids 11 to 202 (192 residues), 191.6 bits, E=1.6e-60
• PF08659: KR
  • amino acids 14 to 187 (174 residues), 30.9 bits, E=3.7e-11
• PF13561: adh_short_C2
  • amino acids 20 to 250 (231 residues), 185.2 bits, E=2.3e-58

Best Hits

Swiss-Prot: 76% identical to KDUD_DICD3: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (kduD) from Dickeya dadantii (strain 3937)

KEGG orthology group: K00065, 2-deoxy-D-gluconate 3-dehydrogenase [EC: 1.1.1.125] (inferred from 87% identity to pva:Pvag_1128)

MetaCyc: 76% identical to KduD (Dickeya dadantii 3937)
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase. [EC: 1.1.1.127]

Predicted SEED Role

"5-keto-D-gluconate 5-reductase (EC 1.1.1.69)" in subsystem D-gluconate and ketogluconates metabolism (EC 1.1.1.69)

MetaCyc Pathways

• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (5/5 steps found)
• ketogluconate metabolism (7/8 steps found)
• 2-deoxy-D-glucose 6-phosphate degradation (3/4 steps found)
• L-idonate degradation (2/3 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.125

Use Curated BLAST to search for 1.1.1.125 or 1.1.1.127 or 1.1.1.69

Protein Sequence (253 amino acids)

>IAI47_11020 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD (Pantoea sp. MT58)
MVLNTFSLESKVAMVTGCNTGLGQGMALGLAQAGCDIVGVNRNGPDDTQSKVEALGRRFW
PVQADLLQTSVVASVVEQALAAAGKIDILVNNAGIIRREDALDFSEQDWDDVMNINSKSL
FFLSQQVARQFIAQGHGGKIINIASMLSFQGGIRVPSYTASKSAVMGLTRLMANEWAKHG
INVNAIAPGYMATNNTEQLRNDASRSEEILGRIPAGRWGVPDDMMGPIVFMASAASDYVN
GYTLAVDGGWLAR