Protein Info for IAI47_10670 in Pantoea sp. MT58

Annotation: SDR family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 7 to 197 (191 residues), 195.1 bits, E=1.4e-61
• PF08659: KR
  • amino acids 9 to 165 (157 residues), 52.3 bits, E=9.9e-18
• PF13561: adh_short_C2
  • amino acids 13 to 245 (233 residues), 227.4 bits, E=2.9e-71

Best Hits

Swiss-Prot: 37% identical to FABG_CHLTR: 3-oxoacyl-[acyl-carrier-protein] reductase FabG (fabG) from Chlamydia trachomatis (strain D/UW-3/Cx)

KEGG orthology group: None (inferred from 94% identity to pva:Pvag_1196)

MetaCyc: 48% identical to meso-butanediol dehydrogenase [(R)-acetoin-forming] (Serratia marcescens H30)
(S,S)-butanediol dehydrogenase. [EC: 1.1.1.76]; RXN-11032 [EC: 1.1.1.76, 1.1.1.304]; 1.1.1.- [EC: 1.1.1.76, 1.1.1.304]

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

MetaCyc Pathways

• pyruvate fermentation to (S)-acetoin (3/3 steps found)
• superpathway of 2,3-butanediol biosynthesis (5/6 steps found)
• (S,S)-butanediol biosynthesis (1/1 steps found)
• (S,S)-butanediol degradation (1/1 steps found)
• meso-butanediol biosynthesis I (1/1 steps found)

KEGG Metabolic Maps

• Butanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.304 or 1.1.1.76

Protein Sequence (254 amino acids)

>IAI47_10670 SDR family oxidoreductase (Pantoea sp. MT58)
MSRFTQKVVVVTGAGSGIGEASAKRFAEEGASVVLVGRTAQKLEETLAGMTPGDHLVAAC
DVSEAEQVKQLSETVLKKYGRVDVLVNNAGVIVQGRVHEVGLDAWKTLMKTDLDGVFHGV
HYFMPALLKSKGNVVNISSVSGLGGDWGMSIYNAAKGAITNFTRALAMDYGADGVRVNAI
CPGFTLTDLTEDASQDQELMERFYDRIPLQRAGKADDIAHAILFIASEEASYITGVNLPV
DGGITASNGQPKQA